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Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies

PURPOSE: Postischemic reperfusion injury may exacerbate cerebral damage and capillary dysfunction, leading to brain edema (BE), hemorrhagic transformation (HT), necrosis, and injury from free radicals with subsequent infarct growth (IG). Several plasmatic biomarkers involved in the ischemic cascade...

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Detalles Bibliográficos
Autores principales: Piccardi, Benedetta, Biagini, Silvia, Iovene, Veronica, Palumbo, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931146/
https://www.ncbi.nlm.nih.gov/pubmed/31903021
http://dx.doi.org/10.1177/1177271919888225
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author Piccardi, Benedetta
Biagini, Silvia
Iovene, Veronica
Palumbo, Vanessa
author_facet Piccardi, Benedetta
Biagini, Silvia
Iovene, Veronica
Palumbo, Vanessa
author_sort Piccardi, Benedetta
collection PubMed
description PURPOSE: Postischemic reperfusion injury may exacerbate cerebral damage and capillary dysfunction, leading to brain edema (BE), hemorrhagic transformation (HT), necrosis, and injury from free radicals with subsequent infarct growth (IG). Several plasmatic biomarkers involved in the ischemic cascade have been studied in relation to radiological and clinical outcomes of reperfusion injury in ischemic stroke with heterogeneous results. This article provides a brief overview of the contribution of circulating biomarkers to the pathophysiology of parenchymal damage in ischemic stroke patients treated with revascularization therapies. METHODS: We included full reports with measurements of plasma markers in patients with acute ischemic stroke treated with revascularization therapies. FINDINGS: Our research included a large number of observational studies investigating a possible role of circulating biomarkers in the development of parenchymal damage after acute stroke treatments. To make the results clearer, we divided the review in 4 sections, exploring the relation of different biomarkers with each of the indicators of parenchymal damage (HT, BE, IG, recanalization). DISCUSSION AND CONCLUSION: Definite conclusions are difficult to draw because of heterogeneity across studies. However, our review seems to confirm an association between some circulating biomarkers (particularly matrix metalloproteinase-9) and occurrence of parenchymal damage in ischemic stroke patients treated with revascularization therapies.
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spelling pubmed-69311462020-01-03 Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies Piccardi, Benedetta Biagini, Silvia Iovene, Veronica Palumbo, Vanessa Biomark Insights Review PURPOSE: Postischemic reperfusion injury may exacerbate cerebral damage and capillary dysfunction, leading to brain edema (BE), hemorrhagic transformation (HT), necrosis, and injury from free radicals with subsequent infarct growth (IG). Several plasmatic biomarkers involved in the ischemic cascade have been studied in relation to radiological and clinical outcomes of reperfusion injury in ischemic stroke with heterogeneous results. This article provides a brief overview of the contribution of circulating biomarkers to the pathophysiology of parenchymal damage in ischemic stroke patients treated with revascularization therapies. METHODS: We included full reports with measurements of plasma markers in patients with acute ischemic stroke treated with revascularization therapies. FINDINGS: Our research included a large number of observational studies investigating a possible role of circulating biomarkers in the development of parenchymal damage after acute stroke treatments. To make the results clearer, we divided the review in 4 sections, exploring the relation of different biomarkers with each of the indicators of parenchymal damage (HT, BE, IG, recanalization). DISCUSSION AND CONCLUSION: Definite conclusions are difficult to draw because of heterogeneity across studies. However, our review seems to confirm an association between some circulating biomarkers (particularly matrix metalloproteinase-9) and occurrence of parenchymal damage in ischemic stroke patients treated with revascularization therapies. SAGE Publications 2019-12-24 /pmc/articles/PMC6931146/ /pubmed/31903021 http://dx.doi.org/10.1177/1177271919888225 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Piccardi, Benedetta
Biagini, Silvia
Iovene, Veronica
Palumbo, Vanessa
Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies
title Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies
title_full Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies
title_fullStr Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies
title_full_unstemmed Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies
title_short Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies
title_sort blood biomarkers of parenchymal damage in ischemic stroke patients treated with revascularization therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931146/
https://www.ncbi.nlm.nih.gov/pubmed/31903021
http://dx.doi.org/10.1177/1177271919888225
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