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Conservative and Surgical Management of Spinal Cord Cavernous Malformations

OBJECTIVES: We present a case series of spinal cord cavernous malformations (SCCMs) to describe clinical presentation and outcomes of both surgical and conservative management. METHODS: The clinical courses of patients diagnosed with SCCMs at our institution were retrospectively reviewed. Neurologic...

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Autores principales: Ohnishi, Yu-ichiro, Nakajima, Nobuhiko, Takenaka, Tomofumi, Fujiwara, Sho, Miura, Shinpei, Terada, Eisaku, Yamada, Shuhei, Kishima, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931213/
https://www.ncbi.nlm.nih.gov/pubmed/31891154
http://dx.doi.org/10.1016/j.wnsx.2019.100066
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author Ohnishi, Yu-ichiro
Nakajima, Nobuhiko
Takenaka, Tomofumi
Fujiwara, Sho
Miura, Shinpei
Terada, Eisaku
Yamada, Shuhei
Kishima, Haruhiko
author_facet Ohnishi, Yu-ichiro
Nakajima, Nobuhiko
Takenaka, Tomofumi
Fujiwara, Sho
Miura, Shinpei
Terada, Eisaku
Yamada, Shuhei
Kishima, Haruhiko
author_sort Ohnishi, Yu-ichiro
collection PubMed
description OBJECTIVES: We present a case series of spinal cord cavernous malformations (SCCMs) to describe clinical presentation and outcomes of both surgical and conservative management. METHODS: The clinical courses of patients diagnosed with SCCMs at our institution were retrospectively reviewed. Neurologic symptoms were evaluated using the Modified McCormick Scale. RESULTS: A total of 18 patients were identified. Five patients (27.8%) presented with acute onset bleeding, 4 of whom underwent immediate surgical resection. Thirteen patients (72.2%) were initially managed conservatively. Eight patients (38.9%) developed a hemorrhage during follow-up, and 8 (38.9%) required surgical resection due to bleeding or neurological worsening. The mean (range) duration from primary symptoms to subsequent hemorrhage or deterioration of symptoms was 1.42 (range: 0.25–4.33) years. The mean duration from primary symptoms to surgery was 2.10 (range: 0.25–5.0) years. No patients experienced subsequent hemorrhage after surgical resection. Eleven patients (84.6%) in the surgery group showed improved neurological status, and 2 patients (15.4%) remained unchanged. The annualized subsequent hemorrhage risk was 3.7%. Patients in the immediate surgical group had a significantly larger lesion compared with those in the conservative group. There was significance between the worst Modified McCormick Scale grades at the time of debilitating symptoms and the length of hemorrhage, but not the size of the lesion. CONCLUSIONS: Surgery for SCCMs resulted in no recurrence of hemorrhage or exacerbation of neurological symptoms, and should be considered for patients who experienced acute onset of hemorrhage or debilitating symptoms during follow-up.
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spelling pubmed-69312132019-12-30 Conservative and Surgical Management of Spinal Cord Cavernous Malformations Ohnishi, Yu-ichiro Nakajima, Nobuhiko Takenaka, Tomofumi Fujiwara, Sho Miura, Shinpei Terada, Eisaku Yamada, Shuhei Kishima, Haruhiko World Neurosurg X Original Article OBJECTIVES: We present a case series of spinal cord cavernous malformations (SCCMs) to describe clinical presentation and outcomes of both surgical and conservative management. METHODS: The clinical courses of patients diagnosed with SCCMs at our institution were retrospectively reviewed. Neurologic symptoms were evaluated using the Modified McCormick Scale. RESULTS: A total of 18 patients were identified. Five patients (27.8%) presented with acute onset bleeding, 4 of whom underwent immediate surgical resection. Thirteen patients (72.2%) were initially managed conservatively. Eight patients (38.9%) developed a hemorrhage during follow-up, and 8 (38.9%) required surgical resection due to bleeding or neurological worsening. The mean (range) duration from primary symptoms to subsequent hemorrhage or deterioration of symptoms was 1.42 (range: 0.25–4.33) years. The mean duration from primary symptoms to surgery was 2.10 (range: 0.25–5.0) years. No patients experienced subsequent hemorrhage after surgical resection. Eleven patients (84.6%) in the surgery group showed improved neurological status, and 2 patients (15.4%) remained unchanged. The annualized subsequent hemorrhage risk was 3.7%. Patients in the immediate surgical group had a significantly larger lesion compared with those in the conservative group. There was significance between the worst Modified McCormick Scale grades at the time of debilitating symptoms and the length of hemorrhage, but not the size of the lesion. CONCLUSIONS: Surgery for SCCMs resulted in no recurrence of hemorrhage or exacerbation of neurological symptoms, and should be considered for patients who experienced acute onset of hemorrhage or debilitating symptoms during follow-up. Elsevier 2019-11-15 /pmc/articles/PMC6931213/ /pubmed/31891154 http://dx.doi.org/10.1016/j.wnsx.2019.100066 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ohnishi, Yu-ichiro
Nakajima, Nobuhiko
Takenaka, Tomofumi
Fujiwara, Sho
Miura, Shinpei
Terada, Eisaku
Yamada, Shuhei
Kishima, Haruhiko
Conservative and Surgical Management of Spinal Cord Cavernous Malformations
title Conservative and Surgical Management of Spinal Cord Cavernous Malformations
title_full Conservative and Surgical Management of Spinal Cord Cavernous Malformations
title_fullStr Conservative and Surgical Management of Spinal Cord Cavernous Malformations
title_full_unstemmed Conservative and Surgical Management of Spinal Cord Cavernous Malformations
title_short Conservative and Surgical Management of Spinal Cord Cavernous Malformations
title_sort conservative and surgical management of spinal cord cavernous malformations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931213/
https://www.ncbi.nlm.nih.gov/pubmed/31891154
http://dx.doi.org/10.1016/j.wnsx.2019.100066
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