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Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping

BACKGROUND: A novel noninvasive epicardial and endocardial electrophysiology system (NEEES) to identify electrical rotors and focal activity in patients with atrial fibrillation (AF) was recently introduced. Comparison of NEEES data with results from invasive mapping is lacking. METHODS: Six male pa...

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Autores principales: Metzner, Andreas, Wissner, Erik, Tsyganov, Alexey, Kalinin, Vitaly, Schlüter, Michael, Lemes, Christine, Mathew, Shibu, Maurer, Tilmann, Heeger, Christian‐Hendrik, Reissmann, Bruno, Ouyang, Feifan, Revishvili, Amiran, Kuck, Karl‐Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931819/
https://www.ncbi.nlm.nih.gov/pubmed/29271538
http://dx.doi.org/10.1111/anec.12527
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author Metzner, Andreas
Wissner, Erik
Tsyganov, Alexey
Kalinin, Vitaly
Schlüter, Michael
Lemes, Christine
Mathew, Shibu
Maurer, Tilmann
Heeger, Christian‐Hendrik
Reissmann, Bruno
Ouyang, Feifan
Revishvili, Amiran
Kuck, Karl‐Heinz
author_facet Metzner, Andreas
Wissner, Erik
Tsyganov, Alexey
Kalinin, Vitaly
Schlüter, Michael
Lemes, Christine
Mathew, Shibu
Maurer, Tilmann
Heeger, Christian‐Hendrik
Reissmann, Bruno
Ouyang, Feifan
Revishvili, Amiran
Kuck, Karl‐Heinz
author_sort Metzner, Andreas
collection PubMed
description BACKGROUND: A novel noninvasive epicardial and endocardial electrophysiology system (NEEES) to identify electrical rotors and focal activity in patients with atrial fibrillation (AF) was recently introduced. Comparison of NEEES data with results from invasive mapping is lacking. METHODS: Six male patients (59 ± 11 years) with persistent AF underwent cardiac mapping with the NEEES, which included the creation of isopotential and phase maps. Then patients underwent catheter mapping using a PentaRay NAV catheter and the CARTO 3 system. Signals acquired by the catheter were analyzed by customized software that applied the same phase mapping algorithm as for the NEEES data. RESULTS: In all patients, noninvasive phase mapping revealed short‐lived electrical rotors occurring 1.8 ± 0.3 times per second and demonstrating 1–4 (mean 1.2 ± 0.6) rotation cycles. Most of these rotors (72.7%) aggregated in 2–3 anatomical clusters. In two patients, focal excitation from pulmonary veins was observed. Invasive catheter mapping in the dominant rotor aggregation sites and in the three control sites demonstrated the presence of electrical rotors with properties similar to noninvasively detected rotors. Spearman's correlation coefficient between rotor occurrence rate by noninvasive and invasive mapping was 0.97 (p < .0001). Mean rotors' cycle length at dominant aggregation sites, scores of their full rotations, and the proportion of rotors with clockwise rotation were not significantly different between the mapping modalities. CONCLUSION: In patients with persistent AF, phase processing of unipolar electrograms recorded by catheter mapping could reproduce electrical rotors as characterized by NEEES‐based phase mapping.
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spelling pubmed-69318192020-03-18 Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping Metzner, Andreas Wissner, Erik Tsyganov, Alexey Kalinin, Vitaly Schlüter, Michael Lemes, Christine Mathew, Shibu Maurer, Tilmann Heeger, Christian‐Hendrik Reissmann, Bruno Ouyang, Feifan Revishvili, Amiran Kuck, Karl‐Heinz Ann Noninvasive Electrocardiol Original Articles BACKGROUND: A novel noninvasive epicardial and endocardial electrophysiology system (NEEES) to identify electrical rotors and focal activity in patients with atrial fibrillation (AF) was recently introduced. Comparison of NEEES data with results from invasive mapping is lacking. METHODS: Six male patients (59 ± 11 years) with persistent AF underwent cardiac mapping with the NEEES, which included the creation of isopotential and phase maps. Then patients underwent catheter mapping using a PentaRay NAV catheter and the CARTO 3 system. Signals acquired by the catheter were analyzed by customized software that applied the same phase mapping algorithm as for the NEEES data. RESULTS: In all patients, noninvasive phase mapping revealed short‐lived electrical rotors occurring 1.8 ± 0.3 times per second and demonstrating 1–4 (mean 1.2 ± 0.6) rotation cycles. Most of these rotors (72.7%) aggregated in 2–3 anatomical clusters. In two patients, focal excitation from pulmonary veins was observed. Invasive catheter mapping in the dominant rotor aggregation sites and in the three control sites demonstrated the presence of electrical rotors with properties similar to noninvasively detected rotors. Spearman's correlation coefficient between rotor occurrence rate by noninvasive and invasive mapping was 0.97 (p < .0001). Mean rotors' cycle length at dominant aggregation sites, scores of their full rotations, and the proportion of rotors with clockwise rotation were not significantly different between the mapping modalities. CONCLUSION: In patients with persistent AF, phase processing of unipolar electrograms recorded by catheter mapping could reproduce electrical rotors as characterized by NEEES‐based phase mapping. John Wiley and Sons Inc. 2017-12-22 /pmc/articles/PMC6931819/ /pubmed/29271538 http://dx.doi.org/10.1111/anec.12527 Text en © 2017 The Authors. Annals of Noninvasive Electrocardiology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Metzner, Andreas
Wissner, Erik
Tsyganov, Alexey
Kalinin, Vitaly
Schlüter, Michael
Lemes, Christine
Mathew, Shibu
Maurer, Tilmann
Heeger, Christian‐Hendrik
Reissmann, Bruno
Ouyang, Feifan
Revishvili, Amiran
Kuck, Karl‐Heinz
Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping
title Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping
title_full Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping
title_fullStr Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping
title_full_unstemmed Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping
title_short Noninvasive phase mapping of persistent atrial fibrillation in humans: Comparison with invasive catheter mapping
title_sort noninvasive phase mapping of persistent atrial fibrillation in humans: comparison with invasive catheter mapping
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931819/
https://www.ncbi.nlm.nih.gov/pubmed/29271538
http://dx.doi.org/10.1111/anec.12527
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