High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media

Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo studies have demonstrated that antimicrobial proteins and peptides (AMPs) are bactericidal against otopathogens, indicating potential therap...

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Detalles Bibliográficos
Autores principales: Seppanen, Elke J., Thornton, Ruth B., Corscadden, Karli J., Granland, Caitlyn M., Hibbert, Julie, Fuery, Angela, Wiertsema, Selma P., Vijayasekaran, Shyan, Coates, Harvey L., Jacoby, Peter, Currie, Andrew, Richmond, Peter C., Kirkham, Lea-Ann S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932785/
https://www.ncbi.nlm.nih.gov/pubmed/31877198
http://dx.doi.org/10.1371/journal.pone.0227080

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