Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains

Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. PALB2 cooperates with BRCA1/2 proteins through physical interaction in initiation of homologous recombination, in maintenance of genome integrity following DNA double-strand b...

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Detalles Bibliográficos
Autores principales: Park, Dongju, Shakya, Reena, Koivisto, Christopher, Pitarresi, Jason R., Szabolcs, Matthias, Kladney, Raleigh, Hadjis, Ashley, Mace, Thomas A., Ludwig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932818/
https://www.ncbi.nlm.nih.gov/pubmed/31877165
http://dx.doi.org/10.1371/journal.pone.0226714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932818/
https://www.ncbi.nlm.nih.gov/pubmed/31877165
http://dx.doi.org/10.1371/journal.pone.0226714

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