Cargando…

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage

DNA damage response (DDR) processes, often caused by oxidative stress, are important in aging and -related disorders. We recently showed that G protein-coupled receptor (GPCR) kinase interacting protein 2 (GIT2) plays a key role in both DNA damage and oxidative stress. Multiple tissue analyses in GI...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Gastel, Jaana, Leysen, Hanne, Santos-Otte, Paula, Hendrickx, Jhana O., Azmi, Abdelkrim, Martin, Bronwen, Maudsley, Stuart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932917/ https://www.ncbi.nlm.nih.gov/pubmed/31794429 http://dx.doi.org/10.18632/aging.102528

Ejemplares similares

G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
por: Leysen, Hanne, et al.
Publicado: (2018)

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence
por: Santos-Otte, Paula, et al.
Publicado: (2019)

β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders
por: van Gastel, Jaana, et al.
Publicado: (2018)

GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders
por: Hendrickx, Jhana O., et al.
Publicado: (2018)

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
por: Leysen, Hanne, et al.
Publicado: (2022)

Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis
por: De Maré, Annelies, et al.
Publicado: (2019)

Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System
por: Janssens, Jonathan, et al.
Publicado: (2014)

Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
por: Kim, Jae Hyung, et al.
Publicado: (2016)

In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family
por: Petrie, Emma J., et al.
Publicado: (2015)

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption
por: Siddiqui, Sana, et al.
Publicado: (2017)

Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat
por: Filonzi, Marcelo, et al.
Publicado: (2007)

Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents
por: Dehghan, Firouzeh, et al.
Publicado: (2016)

GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process
por: Maudsley, Stuart, et al.
Publicado: (2023)

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules
por: Bruell, Shoni, et al.
Publicado: (2013)

Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 & RXFP2) Expression in the Patellar Tendon and Lateral Collateral Ligament of Female WKY Rats
por: Dehghan, Firouzeh, et al.
Publicado: (2014)

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease
por: Leysen, Hanne, et al.
Publicado: (2021)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
por: Kocan, Martina, et al.
Publicado: (2017)

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
por: Praveen, Praveen, et al.
Publicado: (2019)

Familial bilateral cryptorchidism is caused by recessive variants in RXFP2
por: Ayers, Katie, et al.
Publicado: (2019)

Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice
por: Voglsanger, Lara M., et al.
Publicado: (2021)

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
por: Chen, Yan, et al.
Publicado: (2023)

A Proteomic Screen to Unravel the Molecular Pathways Associated with Warfarin-Induced or TNAP-Inhibited Arterial Calcification in Rats
por: Opdebeeck, Britt, et al.
Publicado: (2023)

In Vitro Pharmacological Characterization of RXFP3 Allosterism: An Example of Probe Dependency
por: Alvarez-Jaimes, Lily, et al.
Publicado: (2012)

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
por: Bathgate, Ross A. D., et al.
Publicado: (2013)

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
por: Sethi, Ashish, et al.
Publicado: (2016)

Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice
por: Walker, Andrew W., et al.
Publicado: (2015)

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
por: McBride, Andrew, et al.
Publicado: (2017)

The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
por: Chen, Ting‐Yun, et al.
Publicado: (2020)

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice
por: Haidar, Mouna, et al.
Publicado: (2019)

The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice
por: Ferguson, Lydia, et al.
Publicado: (2013)

Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease
por: Hendrickx, Jhana O., et al.
Publicado: (2021)

Central Role of the EGF Receptor in Neurometabolic Aging
por: Siddiqui, Sana, et al.
Publicado: (2012)

BRET Biosensor Analysis of Receptor Tyrosine Kinase Functionality
por: Siddiqui, Sana, et al.
Publicado: (2013)

Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease
por: Chadwick, Wayne, et al.
Publicado: (2010)

Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin
por: Fernando, Shalinda J.A., et al.
Publicado: (2023)

Cellular Reference Materials for DNA Damage Using Electrochemical Oxidation
por: Atha, Donald H., et al.
Publicado: (2020)

Effective use of latent semantic indexing and computational linguistics in biological and biomedical applications
por: Chen, Hongyu, et al.
Publicado: (2013)

GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
por: Albert-Gascó, Hector, et al.
Publicado: (2018)

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?
por: Smith, Craig M., et al.
Publicado: (2014)

A 1.8‐kb insertion in the 3′‐UTR of RXFP2 is associated with polledness in sheep
por: Wiedemar, Natalie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qgprk5o8m9pobjrjoh70ot8u70