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Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway

Cerebral hypometabolism is a pathophysiological hallmark of Alzheimer’s disease (AD). Our previous studies found that a mitochondrial protein, sirtuin3 (Sirt3), was down-regulated in human AD postmortem brains. Sirt3 protected neurons against oligo-amyloid β-42 induced hypometabolism in human Apolip...

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Detalles Bibliográficos
Autores principales:	Yin, Junxiang, Nielsen, Megan, Carcione, Tanner, Li, Shiping, Shi, Jiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932918/ https://www.ncbi.nlm.nih.gov/pubmed/31808750 http://dx.doi.org/10.18632/aging.102516

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