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Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency

Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the b...

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Detalles Bibliográficos
Autores principales:	Ramos-Pérez, Cristina, Dominska, Margaret, Anaissi-Afonso, Laura, Cazorla-Rivero, Sara, Quevedo, Oliver, Lorenzo-Castrillejo, Isabel, Petes, Thomas D., Machín, Félix
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932922/ https://www.ncbi.nlm.nih.gov/pubmed/31812950 http://dx.doi.org/10.18632/aging.102573

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