Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

PURPOSE: Modulating sialylation of therapeutic glycoproteins may be used to influence their clearance and systemic exposure. We studied the effect of low and high sialylated IL4–10 fusion protein (IL4–10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on...

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Detalles Bibliográficos
Autores principales: Steen-Louws, Cristine, Boross, Peter, Prado, Judith, Meeldijk, Jan, Langenhorst, Jurgen B., Huitema, Alwin D. R., den Hartog, Marcel T., Boon, Louis, Lafeber, Floris P. J. G., Hack, C. Erik, Eijkelkamp, Niels, Popov-Celeketic, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932964/
https://www.ncbi.nlm.nih.gov/pubmed/31879800
http://dx.doi.org/10.1007/s11095-019-2744-y

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