Cargando…

Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis

The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell mechanotransduction and hearing. While channels belonging to SV cell types are known to play crucial roles in EP generation, relatively little is known about gene regulatory net...

Descripción completa

Detalles Bibliográficos
Autores principales:	Korrapati, Soumya, Taukulis, Ian, Olszewski, Rafal, Pyle, Madeline, Gu, Shoujun, Singh, Riya, Griffiths, Carla, Martin, Daniel, Boger, Erich, Morell, Robert J., Hoa, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933021/ https://www.ncbi.nlm.nih.gov/pubmed/31920542 http://dx.doi.org/10.3389/fnmol.2019.00316

Ejemplares similares

Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets
por: Taukulis, Ian A., et al.
Publicado: (2021)

Characterization of rare spindle and root cell transcriptional profiles in the stria vascularis of the adult mouse cochlea
por: Gu, Shoujun, et al.
Publicado: (2020)

Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis
por: Gu, Shoujun, et al.
Publicado: (2021)

Transgenic Tg(Kcnj10-ZsGreen) Fluorescent Reporter Mice Allow Visualization of Intermediate Cells in the Stria Vascularis
por: Strepay, Dillon, et al.
Publicado: (2023)

Tissue-Resident Macrophages in the Stria Vascularis
por: Ito, Taku, et al.
Publicado: (2022)

Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
por: Liu, Huizhan, et al.
Publicado: (2016)

Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome
por: Chen, Linjun, et al.
Publicado: (2020)

Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis
por: Thulasiram, Matsya R, et al.
Publicado: (2022)

Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis
por: Zhang, Na, et al.
Publicado: (2020)

Development of the stria vascularis in the common marmoset, a primate model
por: Hosoya, Makoto, et al.
Publicado: (2022)

Single-cell RNA-sequencing of stria vascularis cells in the adult Slc26a4(-/-) mouse
por: Koh, Jin-Young, et al.
Publicado: (2023)

Estimation of Volume of Stria Vascularis and the Length of Its Capillaries in the Human Cochlea
por: Poorna Pillutla, Sree Vani, et al.
Publicado: (2019)

Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model
por: Jabba, Sairam V, et al.
Publicado: (2006)

Role of the Stria Vascularis in the Pathogenesis of Sensorineural Hearing Loss: A Narrative Review
por: Yu, Wenting, et al.
Publicado: (2021)

The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
por: Li, Hao, et al.
Publicado: (2023)

Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation
por: Bae, Seong Hoon, et al.
Publicado: (2021)

D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
por: Peng, Zhe, et al.
Publicado: (2023)

Attenuating Cardiac Pulsations within the Cochlea: Structure and Function of Tortuous Vessels Feeding Stria Vascularis
por: Carraro, Mattia, et al.
Publicado: (2013)

Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model
por: Xue, Wenyue, et al.
Publicado: (2021)

Corrigendum: Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea
por: Hoa, Michael, et al.
Publicado: (2021)

Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea
por: Hoa, Michael, et al.
Publicado: (2020)

Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss
por: Locher, Heiko, et al.
Publicado: (2015)

Betahistine Exerts a Dose-Dependent Effect on Cochlear Stria Vascularis Blood Flow in Guinea Pigs In Vivo
por: Ihler, Fritz, et al.
Publicado: (2012)

The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion
por: Miyazaki, Hiromitsu, et al.
Publicado: (2016)

The Bed Nucleus of the Stria Terminalis, Homeostatic Satiety, and Compulsions: What Can We Learn From Polydipsia?
por: Banasikowski, Tomek J., et al.
Publicado: (2019)

Epithelial Cell Stretching and Luminal Acidification Lead to a Retarded Development of Stria Vascularis and Deafness in Mice Lacking Pendrin
por: Kim, Hyoung-Mi, et al.
Publicado: (2011)

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
por: Trpchevska, Natalia, et al.
Publicado: (2022)

miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis
por: Gentile, Giulia, et al.
Publicado: (2021)

Pericytes of Stria Vascularis Are Targets of Cisplatin-Induced Ototoxicity: New Insights into the Molecular Mechanisms Involved in Blood-Labyrinth Barrier Breakdown
por: Anfuso, Carmelina Daniela, et al.
Publicado: (2022)

Age-associated variation in the expression and function of TMEM16A calcium-activated chloride channels in the cochlear stria vascularis of guinea pigs
por: Zhou, Ying, et al.
Publicado: (2019)

Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia
por: Nguyen, Phuong Thi Thanh, et al.
Publicado: (2022)

Development of a Serum-Free Culture Method for Endothelial Cells of the Stria Vascularis and Their Pro-inflammatory Secretome Changes Induced by Oxidative Stress
por: Yi, Ying, et al.
Publicado: (2023)

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis
por: Dufek, Brianna, et al.
Publicado: (2020)

The dual role of poly(ADP-ribose) polymerase-1 in modulating parthanatos and autophagy under oxidative stress in rat cochlear marginal cells of the stria vascularis
por: Jiang, Hong-Yan, et al.
Publicado: (2017)

Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
por: Hao, Cong, et al.
Publicado: (2019)

Applications of single‐cell sequencing for the field of otolaryngology: A contemporary review
por: Pyle, Madeline P., et al.
Publicado: (2020)

Neuronal correlates of fear conditioning in the bed nucleus of the stria terminalis
por: Haufler, Darrell, et al.
Publicado: (2013)

Role of the bed nucleus of the stria terminalis in aversive learning and memory
por: Goode, Travis D., et al.
Publicado: (2017)

GLP-1 action in the mouse bed nucleus of the stria terminalis
por: Williams, Diana L., et al.
Publicado: (2018)

Alcohol Exposure Alters NMDAR Function in the Bed Nucleus of the Stria Terminalis
por: Kash, Thomas L., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_c5olfqln3i1nva1ja6oketfbrn