MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway

Oral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the...

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Autores principales: He, Jianya, Ye, Wen, Kou, Ni, Chen, Kang, Cui, Bai, Zhang, Xiaohong, Hu, Shuhai, Liu, Tingjiao, Kang, Lan, Li, Xiaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933408/
https://www.ncbi.nlm.nih.gov/pubmed/31680452
http://dx.doi.org/10.1111/jcmm.14794
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author He, Jianya
Ye, Wen
Kou, Ni
Chen, Kang
Cui, Bai
Zhang, Xiaohong
Hu, Shuhai
Liu, Tingjiao
Kang, Lan
Li, Xiaojie
author_facet He, Jianya
Ye, Wen
Kou, Ni
Chen, Kang
Cui, Bai
Zhang, Xiaohong
Hu, Shuhai
Liu, Tingjiao
Kang, Lan
Li, Xiaojie
author_sort He, Jianya
collection PubMed
description Oral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the miR‐29b‐3p as a guarder that suppressed migration and invasion of OSCC cells and was down‐regulated in the most invasive cells. Besides that, the invasion suppression role of miR‐29b‐3p was achieved through the IL32/AKT pathway. Thus, miR‐29b‐3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC.
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spelling pubmed-69334082020-01-01 MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway He, Jianya Ye, Wen Kou, Ni Chen, Kang Cui, Bai Zhang, Xiaohong Hu, Shuhai Liu, Tingjiao Kang, Lan Li, Xiaojie J Cell Mol Med Original Articles Oral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the miR‐29b‐3p as a guarder that suppressed migration and invasion of OSCC cells and was down‐regulated in the most invasive cells. Besides that, the invasion suppression role of miR‐29b‐3p was achieved through the IL32/AKT pathway. Thus, miR‐29b‐3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC. John Wiley and Sons Inc. 2019-11-03 2020-01 /pmc/articles/PMC6933408/ /pubmed/31680452 http://dx.doi.org/10.1111/jcmm.14794 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
He, Jianya
Ye, Wen
Kou, Ni
Chen, Kang
Cui, Bai
Zhang, Xiaohong
Hu, Shuhai
Liu, Tingjiao
Kang, Lan
Li, Xiaojie
MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
title MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
title_full MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
title_fullStr MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
title_full_unstemmed MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
title_short MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
title_sort microrna‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via il32/akt signalling pathway
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933408/
https://www.ncbi.nlm.nih.gov/pubmed/31680452
http://dx.doi.org/10.1111/jcmm.14794
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