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Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933413/ https://www.ncbi.nlm.nih.gov/pubmed/31642585 http://dx.doi.org/10.1111/jcmm.14745 |
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author | An, Yuanyuan Liu, Fengtian Chen, Ying Yang, Qing |
author_facet | An, Yuanyuan Liu, Fengtian Chen, Ying Yang, Qing |
author_sort | An, Yuanyuan |
collection | PubMed |
description | Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression. |
format | Online Article Text |
id | pubmed-6933413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69334132020-01-01 Crosstalk between cancer‐associated fibroblasts and immune cells in cancer An, Yuanyuan Liu, Fengtian Chen, Ying Yang, Qing J Cell Mol Med Reviews Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression. John Wiley and Sons Inc. 2019-10-23 2020-01 /pmc/articles/PMC6933413/ /pubmed/31642585 http://dx.doi.org/10.1111/jcmm.14745 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews An, Yuanyuan Liu, Fengtian Chen, Ying Yang, Qing Crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
title | Crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
title_full | Crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
title_fullStr | Crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
title_full_unstemmed | Crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
title_short | Crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
title_sort | crosstalk between cancer‐associated fibroblasts and immune cells in cancer |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933413/ https://www.ncbi.nlm.nih.gov/pubmed/31642585 http://dx.doi.org/10.1111/jcmm.14745 |
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