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Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a d...

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Detalles Bibliográficos
Autores principales: An, Yuanyuan, Liu, Fengtian, Chen, Ying, Yang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933413/
https://www.ncbi.nlm.nih.gov/pubmed/31642585
http://dx.doi.org/10.1111/jcmm.14745
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author An, Yuanyuan
Liu, Fengtian
Chen, Ying
Yang, Qing
author_facet An, Yuanyuan
Liu, Fengtian
Chen, Ying
Yang, Qing
author_sort An, Yuanyuan
collection PubMed
description Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.
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spelling pubmed-69334132020-01-01 Crosstalk between cancer‐associated fibroblasts and immune cells in cancer An, Yuanyuan Liu, Fengtian Chen, Ying Yang, Qing J Cell Mol Med Reviews Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression. John Wiley and Sons Inc. 2019-10-23 2020-01 /pmc/articles/PMC6933413/ /pubmed/31642585 http://dx.doi.org/10.1111/jcmm.14745 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
An, Yuanyuan
Liu, Fengtian
Chen, Ying
Yang, Qing
Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
title Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
title_full Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
title_fullStr Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
title_full_unstemmed Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
title_short Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
title_sort crosstalk between cancer‐associated fibroblasts and immune cells in cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933413/
https://www.ncbi.nlm.nih.gov/pubmed/31642585
http://dx.doi.org/10.1111/jcmm.14745
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