l‐tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK‐TRAF6 interactions and inhibiting NF‐κB and MAPK pathways

Bone homeostasis is delicately orchestrated by osteoblasts and osteoclasts. Various pathological bone loss situations result from the overactivated osteoclastogenesis. Receptor activator of nuclear factor κB ligand (RANKL)‐activated NF‐κB and MAPK pathways is vital for osteoclastogenesis. Here, we f...

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Detalles Bibliográficos
Autores principales: Zhi, Xin, Wang, Lipeng, Chen, Huiwen, Fang, Chao, Cui, Jin, Hu, Yan, Cao, Liehu, Weng, Weizong, Zhou, Qirong, Qin, Longjuan, Song, Hongyuan, Wang, Yajun, Wang, Yao, Jiang, Hao, Li, Xiaoqun, Wang, Sicheng, Chen, Xiao, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933417/
https://www.ncbi.nlm.nih.gov/pubmed/31725199
http://dx.doi.org/10.1111/jcmm.14790

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