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Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies
A sequence of transition metal complexes of Mn(II), Co(II), Ni(II), and Cu(II) incorporating a novel pyrimidinyl based Schiff base ligand, 2-(4,6-dimethylpyrimidin-2-ylamino)naphthalene-1,4-dione (HL) and 2,2′-bipyridine has been synthesized and characterized using elemental, magnetic, conductance,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933517/ https://www.ncbi.nlm.nih.gov/pubmed/31921780 http://dx.doi.org/10.3389/fchem.2019.00862 |
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author | Festus, Chioma Okafor, Sunday N. Ekennia, Anthony C. |
author_facet | Festus, Chioma Okafor, Sunday N. Ekennia, Anthony C. |
author_sort | Festus, Chioma |
collection | PubMed |
description | A sequence of transition metal complexes of Mn(II), Co(II), Ni(II), and Cu(II) incorporating a novel pyrimidinyl based Schiff base ligand, 2-(4,6-dimethylpyrimidin-2-ylamino)naphthalene-1,4-dione (HL) and 2,2′-bipyridine has been synthesized and characterized using elemental, magnetic, conductance, infrared (FT-IR), nuclear magnetic resonance ((1)H- and (13)C-NMR), electronic (UV-Vis), electrospray ionization mass spectrometry (ESI-MS), thermographic analysis (TGA), and molecular docking studies. The acquired results were consistent with the adoption of the chemical formula, [M(X)(L)(Y)]·nH(2)O (where M = Mn, Co, Ni, and Cu; L = Schiff base; X = 2,2′-bipy; Y = OAc; and n = 0,1) for the metallic complexes. HL ligand acts as a bidentate chelator and coordinates to metallic ion centre through carbonyl oxygen atom and deprotonated imide nitrogen. Similarly, 2,2′-bipy acts as a non-ionic bidentate chelator coordinating to metallic ion center via two nitrogen atoms. The mixed ligand complexes were appraised against pathogenic strains: S. aureus, P. aeruginosa, E. coli, B. cereus, P. mirabilis, K. oxytoca, A. niger, A. flevus, and R. Stolonifer. The antimicrobial studies gave moderate-good activity. Molecular docking studies on these compounds were done to indicate binding interactions between the compounds and adopted drug targets. Additionally, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the compounds were determined at different concentrations. The antioxidant study showed good radical scavenging abilities. |
format | Online Article Text |
id | pubmed-6933517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69335172020-01-09 Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies Festus, Chioma Okafor, Sunday N. Ekennia, Anthony C. Front Chem Chemistry A sequence of transition metal complexes of Mn(II), Co(II), Ni(II), and Cu(II) incorporating a novel pyrimidinyl based Schiff base ligand, 2-(4,6-dimethylpyrimidin-2-ylamino)naphthalene-1,4-dione (HL) and 2,2′-bipyridine has been synthesized and characterized using elemental, magnetic, conductance, infrared (FT-IR), nuclear magnetic resonance ((1)H- and (13)C-NMR), electronic (UV-Vis), electrospray ionization mass spectrometry (ESI-MS), thermographic analysis (TGA), and molecular docking studies. The acquired results were consistent with the adoption of the chemical formula, [M(X)(L)(Y)]·nH(2)O (where M = Mn, Co, Ni, and Cu; L = Schiff base; X = 2,2′-bipy; Y = OAc; and n = 0,1) for the metallic complexes. HL ligand acts as a bidentate chelator and coordinates to metallic ion centre through carbonyl oxygen atom and deprotonated imide nitrogen. Similarly, 2,2′-bipy acts as a non-ionic bidentate chelator coordinating to metallic ion center via two nitrogen atoms. The mixed ligand complexes were appraised against pathogenic strains: S. aureus, P. aeruginosa, E. coli, B. cereus, P. mirabilis, K. oxytoca, A. niger, A. flevus, and R. Stolonifer. The antimicrobial studies gave moderate-good activity. Molecular docking studies on these compounds were done to indicate binding interactions between the compounds and adopted drug targets. Additionally, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the compounds were determined at different concentrations. The antioxidant study showed good radical scavenging abilities. Frontiers Media S.A. 2019-12-20 /pmc/articles/PMC6933517/ /pubmed/31921780 http://dx.doi.org/10.3389/fchem.2019.00862 Text en Copyright © 2019 Festus, Okafor and Ekennia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Festus, Chioma Okafor, Sunday N. Ekennia, Anthony C. Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies |
title | Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies |
title_full | Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies |
title_fullStr | Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies |
title_full_unstemmed | Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies |
title_short | Heteroleptic Metal Complexes of a Pyrimidinyl Based Schiff Base Ligand Incorporating 2,2′-Bipyridine Moiety: Synthesis, Characterization, and Biological Studies |
title_sort | heteroleptic metal complexes of a pyrimidinyl based schiff base ligand incorporating 2,2′-bipyridine moiety: synthesis, characterization, and biological studies |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933517/ https://www.ncbi.nlm.nih.gov/pubmed/31921780 http://dx.doi.org/10.3389/fchem.2019.00862 |
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