Developing Modern Pain Therapies

Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essential. We discuss here recent progress in the under...

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Autores principales: Manion, John, Waller, Matthew A., Clark, Teleri, Massingham, Joshua N., Neely, G. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933609/
https://www.ncbi.nlm.nih.gov/pubmed/31920521
http://dx.doi.org/10.3389/fnins.2019.01370
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author Manion, John
Waller, Matthew A.
Clark, Teleri
Massingham, Joshua N.
Neely, G. Gregory
author_facet Manion, John
Waller, Matthew A.
Clark, Teleri
Massingham, Joshua N.
Neely, G. Gregory
author_sort Manion, John
collection PubMed
description Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essential. We discuss here recent progress in the understanding of mechanisms underlying pain, and how these mechanisms are being targeted to produce modern, specific therapies for pain. Finally, we make recommendations for the next generation of targeted, effective, and safe pain therapies.
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spelling pubmed-69336092020-01-09 Developing Modern Pain Therapies Manion, John Waller, Matthew A. Clark, Teleri Massingham, Joshua N. Neely, G. Gregory Front Neurosci Neuroscience Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essential. We discuss here recent progress in the understanding of mechanisms underlying pain, and how these mechanisms are being targeted to produce modern, specific therapies for pain. Finally, we make recommendations for the next generation of targeted, effective, and safe pain therapies. Frontiers Media S.A. 2019-12-20 /pmc/articles/PMC6933609/ /pubmed/31920521 http://dx.doi.org/10.3389/fnins.2019.01370 Text en Copyright © 2019 Manion, Waller, Clark, Massingham and Neely. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Manion, John
Waller, Matthew A.
Clark, Teleri
Massingham, Joshua N.
Neely, G. Gregory
Developing Modern Pain Therapies
title Developing Modern Pain Therapies
title_full Developing Modern Pain Therapies
title_fullStr Developing Modern Pain Therapies
title_full_unstemmed Developing Modern Pain Therapies
title_short Developing Modern Pain Therapies
title_sort developing modern pain therapies
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933609/
https://www.ncbi.nlm.nih.gov/pubmed/31920521
http://dx.doi.org/10.3389/fnins.2019.01370
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