Cargando…

IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway

We previously reported that astrocyte-derived proinflammatory cytokine interleukin (IL)-17A could aggravate neuronal ischemic injuries and strength autophagy both in oxygen-glucose deprivation (OGD)/reoxygenation (R)-treated neurons and peri-infarct region of mice with middle cerebral artery occlusi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Ting, Han, Song, Dai, Qingqing, Zheng, Jiayin, Liu, Cui, Li, Shujuan, Li, Junfa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933613/ https://www.ncbi.nlm.nih.gov/pubmed/31921197 http://dx.doi.org/10.3389/fimmu.2019.02952

Ejemplares similares

IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis
por: Dai, Qingqing, et al.
Publicado: (2020)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

cPKCγ-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion
por: Hua, Rongrong, et al.
Publicado: (2018)

ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway
por: Han, Xiao, et al.
Publicado: (2022)

Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation
por: Roy, Tithi, et al.
Publicado: (2023)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway
por: Xu, Jun, et al.
Publicado: (2020)

Periodontitis Salivary Microbiota Aggravates Ischemic Stroke Through IL-17A
por: Chen, Yan-Lin, et al.
Publicado: (2022)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

The mTOR inhibition in concurrence with ERK1/2 activation is involved in excessive autophagy induced by glycyrrhizin in hepatocellular carcinoma
por: Zhang, Xuan, et al.
Publicado: (2017)

IL-17A regulates autophagy and promotes osteoclast differentiation through the ERK/mTOR/Beclin1 pathway
por: Tang, Hao, et al.
Publicado: (2023)

Acute, Delayed and Chronic Remote Ischemic Conditioning Is Associated with Downregulation of mTOR and Enhanced Autophagy Signaling
por: Rohailla, Sagar, et al.
Publicado: (2014)

cPKCγ‐mediated down‐regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK‐mTOR pathway
por: Zhang, Dan, et al.
Publicado: (2017)

Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis
por: Zhou, Xindie, et al.
Publicado: (2020)

SeMet attenuates OTA-induced PCV2 replication promotion by inhibiting autophagy by activating the AKT/mTOR signaling pathway
por: Qian, Gang, et al.
Publicado: (2018)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease
por: Zhu, Zhou, et al.
Publicado: (2019)

mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells
por: Colella, Barbara, et al.
Publicado: (2020)

mTOR Overactivation in Mesenchymal cells Aggravates CCl(4)− Induced liver Fibrosis
por: Shan, Lanlan, et al.
Publicado: (2016)

Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
por: Kroh, Andreas, et al.
Publicado: (2023)

Study on the Mechanism of mTOR-Mediated Autophagy during Electroacupuncture Pretreatment against Cerebral Ischemic Injury
por: Wu, Zhou-Quan, et al.
Publicado: (2016)

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
por: Wang, Haojie, et al.
Publicado: (2019)

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice
por: Li, Xiao, et al.
Publicado: (2017)

mTOR's role in ageing: protein synthesis or autophagy?
por: Hands, Sarah L., et al.
Publicado: (2009)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis
por: Matozaki, Takashi, et al.
Publicado: (2020)

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
por: Gui, Yao-Song, et al.
Publicado: (2015)

Hirudin inhibits glioma growth through mTOR‐regulated autophagy
por: Ma, Ying, et al.
Publicado: (2023)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

Hyperglycemia aggravates acute liver injury by promoting liver‐resident macrophage NLRP3 inflammasome activation via the inhibition of AMPK/mTOR‐mediated autophagy induction
por: Wang, Qi, et al.
Publicado: (2019)

Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy
por: Wu, Yuanyuan, et al.
Publicado: (2020)

Coxsackievirus A16 Elicits Incomplete Autophagy Involving the mTOR and ERK Pathways
por: Shi, Yingying, et al.
Publicado: (2015)

Pleiotropic Effects of mTOR and Autophagy During Development and Aging
por: Schmeisser, Kathrin, et al.
Publicado: (2019)

mTORC2: The other mTOR in autophagy regulation
por: Ballesteros‐Álvarez, Josué, et al.
Publicado: (2021)

Celastrol promotes chondrocyte autophagy by regulating mTOR expression
por: Dai, Siming, et al.
Publicado: (2022)

Role of mTOR through Autophagy in Esophageal Cancer Stemness
por: Du, Liang, et al.
Publicado: (2022)

Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro
por: He, Caigu, et al.
Publicado: (2020)

Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway
por: Liu, Xingyun, et al.
Publicado: (2021)

P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy
por: Huang, Liangliang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cougtiv7ei0lradto4nd08q7d0