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Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS
BACKGROUND: The Symbol Digit Modalities Test (SDMT) is regarded as the cognitive test of choice for people with MS (pwMS). While deficits are linked to impaired processing speed, the mechanisms by which they arise are unclear. Cognitive-mediated eye movements offer one putative explanation. The obje...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933713/ https://www.ncbi.nlm.nih.gov/pubmed/31878918 http://dx.doi.org/10.1186/s12883-019-1543-8 |
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author | Pavisian, Bennis Patel, Viral P. Feinstein, Anthony |
author_facet | Pavisian, Bennis Patel, Viral P. Feinstein, Anthony |
author_sort | Pavisian, Bennis |
collection | PubMed |
description | BACKGROUND: The Symbol Digit Modalities Test (SDMT) is regarded as the cognitive test of choice for people with MS (pwMS). While deficits are linked to impaired processing speed, the mechanisms by which they arise are unclear. Cognitive-mediated eye movements offer one putative explanation. The objective of this study was to determine the association between eye movements and performance on the SDMT. METHODS: Thirty-three people with confirmed MS and 25 matched healthy control subjects (HC) were administered the oral SDMT while eye movements were recorded. RESULTS: Mean SDMT scores were significantly lower in pwMS (p < 0.038). Shorter mean saccade distance in the key area (p = 0.007), more visits to the key area per response (p = 0.014), and more total number of fixations in the test area (p = 0.045) differentiated pwMS from HCs. A hierarchical regression analysis revealed that the number of visits to the key area per response (p < 0.001; ΔR(2) = 0.549) and total number of fixations in the test area (p < 0.001; ΔR(2) = 0.782) were the most robust predictors of SDMT scores. CONCLUSION: Cognitive-mediated eye movements help elucidate the processing speed challenges confronted by people with MS. Mechanistic insights such as these can potentially help inform new cognitive rehabilitation strategies. |
format | Online Article Text |
id | pubmed-6933713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69337132019-12-30 Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS Pavisian, Bennis Patel, Viral P. Feinstein, Anthony BMC Neurol Research Article BACKGROUND: The Symbol Digit Modalities Test (SDMT) is regarded as the cognitive test of choice for people with MS (pwMS). While deficits are linked to impaired processing speed, the mechanisms by which they arise are unclear. Cognitive-mediated eye movements offer one putative explanation. The objective of this study was to determine the association between eye movements and performance on the SDMT. METHODS: Thirty-three people with confirmed MS and 25 matched healthy control subjects (HC) were administered the oral SDMT while eye movements were recorded. RESULTS: Mean SDMT scores were significantly lower in pwMS (p < 0.038). Shorter mean saccade distance in the key area (p = 0.007), more visits to the key area per response (p = 0.014), and more total number of fixations in the test area (p = 0.045) differentiated pwMS from HCs. A hierarchical regression analysis revealed that the number of visits to the key area per response (p < 0.001; ΔR(2) = 0.549) and total number of fixations in the test area (p < 0.001; ΔR(2) = 0.782) were the most robust predictors of SDMT scores. CONCLUSION: Cognitive-mediated eye movements help elucidate the processing speed challenges confronted by people with MS. Mechanistic insights such as these can potentially help inform new cognitive rehabilitation strategies. BioMed Central 2019-12-26 /pmc/articles/PMC6933713/ /pubmed/31878918 http://dx.doi.org/10.1186/s12883-019-1543-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Pavisian, Bennis Patel, Viral P. Feinstein, Anthony Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS |
title | Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS |
title_full | Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS |
title_fullStr | Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS |
title_full_unstemmed | Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS |
title_short | Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS |
title_sort | cognitive mediated eye movements during the sdmt reveal the challenges with processing speed faced by people with ms |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933713/ https://www.ncbi.nlm.nih.gov/pubmed/31878918 http://dx.doi.org/10.1186/s12883-019-1543-8 |
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