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Chromenones as Multineurotargeting Inhibitors of Human Enzymes
[Image: see text] The complex nature of multifactorial diseases, such as Morbus Alzheimer, has produced a strong need to design multitarget-directed ligands to address the involved complementary pathways. We performed a purposive structural modification of a tetratarget small-molecule, that is conti...
Autores principales: | Lemke, Carina, Christmann, Joscha, Yin, Jiafei, Alonso, José M., Serrano, Estefanía, Chioua, Mourad, Ismaili, Lhassane, Martínez-Grau, María Angeles, Beadle, Christopher D., Vetman, Tatiana, Dato, Florian M., Bartz, Ulrike, Elsinghorst, Paul W., Pietsch, Markus, Müller, Christa E., Iriepa, Isabel, Wille, Timo, Marco-Contelles, José, Gütschow, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933783/ https://www.ncbi.nlm.nih.gov/pubmed/31891098 http://dx.doi.org/10.1021/acsomega.9b03409 |
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