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Particulate Systems in the Enhancement of the Antiglaucomatous Drug Pharmacodynamics: A Meta-Analysis Study
[Image: see text] Glaucoma is a very serious disease that can lead to blindness in severe cases. In an attempt to increase the efficacy of the drugs used in treating this disease, many particulate systems (micro/nano and lipid-based/nonlipid-based) have been exploited. In this study, the meta-analys...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Chemical
Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933800/ https://www.ncbi.nlm.nih.gov/pubmed/31891069 http://dx.doi.org/10.1021/acsomega.9b02895 |
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author | Hathout, Rania M. |
author_facet | Hathout, Rania M. |
author_sort | Hathout, Rania M. |
collection | PubMed |
description | [Image: see text] Glaucoma is a very serious disease that can lead to blindness in severe cases. In an attempt to increase the efficacy of the drugs used in treating this disease, many particulate systems (micro/nano and lipid-based/nonlipid-based) have been exploited. In this study, the meta-analysis approach was implemented in order to explore the published studies and extract the literature-based evidence (proof-of-concept studies = 16) that the particulate systems increase the efficiency of the investigated intraocular pressure drugs as demonstrated by the increase in the area under effect curve. Comparison of micron particles versus nanoparticles on the one hand and lipid-based versus nonlipid-based on the other hand, as subgroups of the meta-analysis, was also included in the study where the latter comparison led to insignificant differences, whereas the former has proven the superiority of the nanoparticles over the micronized counterparts. |
format | Online Article Text |
id | pubmed-6933800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-69338002019-12-30 Particulate Systems in the Enhancement of the Antiglaucomatous Drug Pharmacodynamics: A Meta-Analysis Study Hathout, Rania M. ACS Omega [Image: see text] Glaucoma is a very serious disease that can lead to blindness in severe cases. In an attempt to increase the efficacy of the drugs used in treating this disease, many particulate systems (micro/nano and lipid-based/nonlipid-based) have been exploited. In this study, the meta-analysis approach was implemented in order to explore the published studies and extract the literature-based evidence (proof-of-concept studies = 16) that the particulate systems increase the efficiency of the investigated intraocular pressure drugs as demonstrated by the increase in the area under effect curve. Comparison of micron particles versus nanoparticles on the one hand and lipid-based versus nonlipid-based on the other hand, as subgroups of the meta-analysis, was also included in the study where the latter comparison led to insignificant differences, whereas the former has proven the superiority of the nanoparticles over the micronized counterparts. American Chemical Society 2019-12-16 /pmc/articles/PMC6933800/ /pubmed/31891069 http://dx.doi.org/10.1021/acsomega.9b02895 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Hathout, Rania M. Particulate Systems in the Enhancement of the Antiglaucomatous Drug Pharmacodynamics: A Meta-Analysis Study |
title | Particulate Systems
in the Enhancement of the Antiglaucomatous
Drug Pharmacodynamics: A Meta-Analysis Study |
title_full | Particulate Systems
in the Enhancement of the Antiglaucomatous
Drug Pharmacodynamics: A Meta-Analysis Study |
title_fullStr | Particulate Systems
in the Enhancement of the Antiglaucomatous
Drug Pharmacodynamics: A Meta-Analysis Study |
title_full_unstemmed | Particulate Systems
in the Enhancement of the Antiglaucomatous
Drug Pharmacodynamics: A Meta-Analysis Study |
title_short | Particulate Systems
in the Enhancement of the Antiglaucomatous
Drug Pharmacodynamics: A Meta-Analysis Study |
title_sort | particulate systems
in the enhancement of the antiglaucomatous
drug pharmacodynamics: a meta-analysis study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933800/ https://www.ncbi.nlm.nih.gov/pubmed/31891069 http://dx.doi.org/10.1021/acsomega.9b02895 |
work_keys_str_mv | AT hathoutraniam particulatesystemsintheenhancementoftheantiglaucomatousdrugpharmacodynamicsametaanalysisstudy |