Large cell neuroendocrine carcinoma with a solitary brain metastasis and low Ki-67: a unique subtype

INTRODUCTION: Stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung generally presents as disseminated and aggressive disease with a Ki-67 proliferation index (PI) 40–80%. LCNEC can be subdivided in two main subtypes: the first harboring TP53/RB1 mutations (small-cell lung carcinoma (SCLC...

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Detalles Bibliográficos
Autores principales: Hermans, B C M, Derks, J L, Groen, H J M, Stigt, J A, van Suylen, R J, Hillen, L M, van den Broek, E C, Speel, E J M, Dingemans, A-M C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933830/
https://www.ncbi.nlm.nih.gov/pubmed/31751303
http://dx.doi.org/10.1530/EC-19-0372

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