Effect of Kenacort on Pregnant Wistar Albino Rats

Kenacort is a well-known synthetic glucocorticoid used in today's medical practice for various therapeutic uses. The drug has been known to induce cleft palate in rodents in specific doses. This study uses triamcinolone acetonide (TAC) as a teratogen for inducing cleft palate in rat embryos. Th...

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Detalles Bibliográficos
Autores principales: Amalraj, Julie Christy, Charanya, N., Perumal, Saraswathi, Sathialakshmi, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Original Article - Evaluative Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933983/
https://www.ncbi.nlm.nih.gov/pubmed/31909003
http://dx.doi.org/10.4103/ams.ams_141_16
Descripción
Sumario:Kenacort is a well-known synthetic glucocorticoid used in today's medical practice for various therapeutic uses. The drug has been known to induce cleft palate in rodents in specific doses. This study uses triamcinolone acetonide (TAC) as a teratogen for inducing cleft palate in rat embryos. The study discusses the molecular level action of TAC on the palatal mucosa in the rat palate. This study substantiates that the TAC given during the first trimester between 29(th) and 38(th) day of gestation can induce many congenital anomalies. The study shows an animal model to depict the drug toxicity on the pregnant Wistar albino rats.

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