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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the...

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Detalles Bibliográficos
Autores principales:	Wang, Yufang, Shi, Peiliang, Chen, Qin, Huang, Zan, Zou, Dayuan, Zhang, Jingzi, Gao, Xiang, Lin, Zhaoyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934151/ https://www.ncbi.nlm.nih.gov/pubmed/30860577 http://dx.doi.org/10.1093/jmcb/mjz020

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