Cargando…

KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan

BACKGROUND: A constitutively active RAS protein in the absence of stimulation of the epidermal growth factor receptor (EGFR) is the result of mutations in KRAS and NRAS genes. Mutations in the KRAS exon 2 and outside exon 2 have been found to predict the resistance to anti-EGFR monoclonal therapy. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Awidi, Muhammad, Ababneh, Nidaa, Shomaf, Maha, Al Fararjeh, Feras, Owaidi, Laila, AlKhatib, Mohammad, Al Tarawneh, Buthaina, Awidi, Abdalla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934288/ https://www.ncbi.nlm.nih.gov/pubmed/31881025 http://dx.doi.org/10.1371/journal.pone.0226473

Ejemplares similares

A comparative study of the capability of MSCs isolated from different human tissue sources to differentiate into neuronal stem cells and dopaminergic-like cells
por: Ababneh, Nidaa A., et al.
Publicado: (2022)

Real World Multiple Myeloma Registry from Jordan, a Developing Country
por: Qasem, Farah, et al.
Publicado: (2022)

Use of conditioned media (CM) and xeno-free serum substitute on human adipose-derived stem cells (ADSCs) differentiation into urothelial-like cells
por: kurdi, Ban Al-, et al.
Publicado: (2021)

Contributing factors to iron deficiency anemia in women in Jordan: A single-center cross-sectional study
por: Awidi, Muhammad, et al.
Publicado: (2018)

Phytochemical Analysis and Anticancer Properties of Drimia maritima Bulb Extracts on Colorectal Cancer Cells
por: Al-Abdallat, Khairallah, et al.
Publicado: (2023)

A Descriptive Study of the Physical Direct Interaction between Adipose Tissue-Mesenchymal Stem Cells and Colo 205 Cells: Impact on Cancer Cells Stemness, and Intracellular Reactive Oxygen Species Levels
por: Sharar, Nour, et al.
Publicado: (2022)

Impact of KRAS Mutation on Survival Outcome of Patients With Metastatic Colorectal Cancer in Jordan
por: Alkader, Mohammad S, et al.
Publicado: (2023)

The predictive value of KRAS and NRAS mutations in metastatic colorectal cancer
por: Eshraghi, Abbas, et al.
Publicado: (2020)

hPL promotes osteogenic differentiation of stem cells in 3D scaffolds
por: Jafar, Hanan, et al.
Publicado: (2019)

Low Incidence of the DPD IVS14+1G>A Polymorphism in Jordanian Breast and Colorectal Cancer patients
por: Al-Khateeb, Mohammad, et al.
Publicado: (2017)

Identification of APTX disease-causing mutation in two unrelated Jordanian families with cerebellar ataxia and sensitivity to DNA damaging agents
por: Ababneh, Nidaa A., et al.
Publicado: (2020)

The effect of platelet lysate in culture of PDLSCs: an in vitro comparative study
por: Abuarqoub, Duaa A., et al.
Publicado: (2019)

Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients
por: Hsu, Hung-Chih, et al.
Publicado: (2016)

Jordan’s Population-Based Food Consumption Survey: Protocol for Design and Development
por: Al-Shami, Islam, et al.
Publicado: (2023)

Correction: Selection and targeting of EpCAM protein by ssDNA aptamer
por: Alshaer, Walhan, et al.
Publicado: (2018)

Prevalence of blood-borne viral infections among autopsy cases in Jordan
por: Bakri, Faris G., et al.
Publicado: (2017)

Mesenchymal stem cells and conditioned media in the treatment of multiple sclerosis patients: Clinical, ophthalmological and radiological assessments of safety and efficacy
por: Dahbour, Said, et al.
Publicado: (2017)

FOLFIRI plus panitumumab in the treatment of wild-type KRAS and wild-type NRAS metastatic colorectal cancer
por: Geredeli, Caglayan, et al.
Publicado: (2018)

KRAS, NRAS, BRAF, HER2 and Microsatellite Instability in Metastatic Colorectal Cancer – Practical Implications for the Clinician
por: Afrăsânie, Vlad-Adrian, et al.
Publicado: (2019)

Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer
por: Bożyk, Aleksandra, et al.
Publicado: (2021)

Unique Variant Spectrum in a Jordanian Cohort with Inherited Retinal Dystrophies
por: Azab, Bilal, et al.
Publicado: (2021)

BRCA1 and BRCA2 genes mutations among high risk breast cancer patients in Jordan
por: Abu-Helalah, Munir, et al.
Publicado: (2020)

KRAS and NRAS pyrosequencing screening in Tunisian colorectal cancer patients in 2015
por: Jouini, Raja, et al.
Publicado: (2019)

Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer
por: Franczak, Claire, et al.
Publicado: (2020)

Energy and macronutrient intakes in Jordan: a population study
por: Al Hourani, Huda, et al.
Publicado: (2023)

Molecular Pattern and Clinical Implications of KRAS/NRAS and BRAF Mutations in Colorectal Cancer
por: Gökmen, İvo, et al.
Publicado: (2023)

Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regarding COVID-19 among Students at the University of Jordan
por: Sallam, Malik, et al.
Publicado: (2020)

Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan
por: Ababneh, Nidaa A., et al.
Publicado: (2019)

Effect of KRAS and NRAS mutations on the prognosis of patients with synchronous metastatic colorectal cancer presenting with liver-only and lung-only metastases
por: Chuang, Shih-Chang, et al.
Publicado: (2020)

A Systematic Literature Review and Meta-Analysis Describing the Prevalence of KRAS, NRAS, and BRAF Gene Mutations in Metastatic Colorectal Cancer
por: Levin-Sparenberg, Elizabeth, et al.
Publicado: (2020)

Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR
por: Nagakubo, Yuki, et al.
Publicado: (2019)

Clinicopathological characteristics and mutational profile of KRAS and NRAS in Tunisian patients with sporadic colorectal cancer
por: OUNISSI, Donia, et al.
Publicado: (2021)

KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer
por: Saharti, Samah
Publicado: (2022)

High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE ‐ hypermutated colorectal cancers
por: Favre, Loetitia, et al.
Publicado: (2022)

KRAS, NRAS, BRAF signatures, and MMR status in colorectal cancer patients in North China
por: Lian, Shen-Yi, et al.
Publicado: (2023)

Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group
por: Modest, D. P., et al.
Publicado: (2016)

Seroprevalence and risk factors for bovine brucellosis in Jordan
por: Al-Majali, Ahmad M., et al.
Publicado: (2009)

Colorectal Cancer in Jordan: Survival Rate and Its Related Factors
por: Sharkas, Ghazi Faisal, et al.
Publicado: (2017)

Molecular genetics of phenylketonuria and tetrahydrobiopterin deficiency in Jordan
por: Carducci, Carla, et al.
Publicado: (2020)

Human Wharton’s Jelly-Derived Mesenchymal Stromal Cells Primed by Tumor Necrosis Factor-α and Interferon-γ Modulate the Innate and Adaptive Immune Cells of Type 1 Diabetic Patients
por: Mrahleh, Mairvat Al-, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5emr7i2lj5s6ds52i4ncmelasn