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KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan

BACKGROUND: A constitutively active RAS protein in the absence of stimulation of the epidermal growth factor receptor (EGFR) is the result of mutations in KRAS and NRAS genes. Mutations in the KRAS exon 2 and outside exon 2 have been found to predict the resistance to anti-EGFR monoclonal therapy. A...

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Detalles Bibliográficos
Autores principales:	Awidi, Muhammad, Ababneh, Nidaa, Shomaf, Maha, Al Fararjeh, Feras, Owaidi, Laila, AlKhatib, Mohammad, Al Tarawneh, Buthaina, Awidi, Abdalla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934288/ https://www.ncbi.nlm.nih.gov/pubmed/31881025 http://dx.doi.org/10.1371/journal.pone.0226473

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