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The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis

Pharmacological interventions to aid weight loss have historically targeted either appetite suppression or increased metabolic rate. Brown adipose tissue (BAT) possesses the capacity to expend energy in a futile cycle, thus increasing basal metabolic rate. In animal models, oestrogen has been implic...

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Autores principales: Sievers, Will, Rathner, Joseph A., Kettle, Christine, Zacharias, Anita, Irving, Helen R., Green, Rodney A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934433/
https://www.ncbi.nlm.nih.gov/pubmed/31890250
http://dx.doi.org/10.1002/osp4.368
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author Sievers, Will
Rathner, Joseph A.
Kettle, Christine
Zacharias, Anita
Irving, Helen R.
Green, Rodney A.
author_facet Sievers, Will
Rathner, Joseph A.
Kettle, Christine
Zacharias, Anita
Irving, Helen R.
Green, Rodney A.
author_sort Sievers, Will
collection PubMed
description Pharmacological interventions to aid weight loss have historically targeted either appetite suppression or increased metabolic rate. Brown adipose tissue (BAT) possesses the capacity to expend energy in a futile cycle, thus increasing basal metabolic rate. In animal models, oestrogen has been implicated in the regulation of body weight, and it is hypothesized that oestrogen is acting by modulating BAT metabolism. A systematic search was performed, to identify research articles implementing in vivo oestrogen‐related interventions and reporting outcome measures that provide direct or indirect measures of BAT metabolism. Meta‐analyses were conducted where sufficient data were available. The final library of 67 articles were predominantly in rodent models and provided mostly indirect measures of BAT metabolism. Results of this review found that oestrogen's effects on body weight, in rats and possibly mice, are likely facilitated by both metabolic and appetitive mechanisms but are largely only found in ovariectomized models. There is a need for further studies to clarify the potential effects of oestrogen on BAT metabolism in gonad‐intact and castrated male animal models.
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spelling pubmed-69344332019-12-30 The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis Sievers, Will Rathner, Joseph A. Kettle, Christine Zacharias, Anita Irving, Helen R. Green, Rodney A. Obes Sci Pract Reviews Pharmacological interventions to aid weight loss have historically targeted either appetite suppression or increased metabolic rate. Brown adipose tissue (BAT) possesses the capacity to expend energy in a futile cycle, thus increasing basal metabolic rate. In animal models, oestrogen has been implicated in the regulation of body weight, and it is hypothesized that oestrogen is acting by modulating BAT metabolism. A systematic search was performed, to identify research articles implementing in vivo oestrogen‐related interventions and reporting outcome measures that provide direct or indirect measures of BAT metabolism. Meta‐analyses were conducted where sufficient data were available. The final library of 67 articles were predominantly in rodent models and provided mostly indirect measures of BAT metabolism. Results of this review found that oestrogen's effects on body weight, in rats and possibly mice, are likely facilitated by both metabolic and appetitive mechanisms but are largely only found in ovariectomized models. There is a need for further studies to clarify the potential effects of oestrogen on BAT metabolism in gonad‐intact and castrated male animal models. John Wiley and Sons Inc. 2019-11-11 /pmc/articles/PMC6934433/ /pubmed/31890250 http://dx.doi.org/10.1002/osp4.368 Text en © 2019 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Sievers, Will
Rathner, Joseph A.
Kettle, Christine
Zacharias, Anita
Irving, Helen R.
Green, Rodney A.
The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis
title The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis
title_full The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis
title_fullStr The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis
title_full_unstemmed The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis
title_short The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis
title_sort capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: a systematic review and meta‐analysis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934433/
https://www.ncbi.nlm.nih.gov/pubmed/31890250
http://dx.doi.org/10.1002/osp4.368
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