High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls

Chronic obstructive pulmonary disease (COPD) is induced by cigarette smoking and characterized by inflammation of airway tissue. Since smokers with COPD have a higher risk of developing lung cancer than those without, we hypothesized that they carry more mutations in affected tissue. We called somat...

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Detalles Bibliográficos
Autores principales: Thun, Gian-Andri, Derdak, Sophia, Castro-Giner, Francesc, Apunte-Ramos, Katherine, Águeda, Lidia, Wjst, Matthias, Boland, Anne, Deleuze, Jean-François, Kolsum, Umme, Heiss-Neumann, Marion S., Nowinski, Adam, Gorecka, Dorota, Hohlfeld, Jens M., Welte, Tobias, Brightling, Christopher E., Parr, David G., Prasse, Antje, Müller-Quernheim, Joachim, Greulich, Timm, Stendardo, Mariarita, Boschetto, Piera, Barta, Imre, Döme, Balázs, Gut, Marta, Singh, Dave, Ziegler-Heitbrock, Loems, Gut, Ivo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934450/
https://www.ncbi.nlm.nih.gov/pubmed/31882973
http://dx.doi.org/10.1038/s41598-019-56618-1

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