Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2

We have investigated covalent conjugation of VPPPVPPRRRX′ peptide (where X′ denotes N(ε)-chloroacetyl lysine) to N-terminal SH3 domain from adapter protein Grb2. Our experimental results confirmed that the peptide first binds to the SH3 domain noncovalently before establishing a covalent linkage thr...

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Detalles Bibliográficos
Autores principales: Luzik, Dmitrii A., Rogacheva, Olga N., Izmailov, Sergei A., Indeykina, Maria I., Kononikhin, Alexei S., Skrynnikov, Nikolai R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934455/
https://www.ncbi.nlm.nih.gov/pubmed/31882608
http://dx.doi.org/10.1038/s41598-019-56078-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934455/
https://www.ncbi.nlm.nih.gov/pubmed/31882608
http://dx.doi.org/10.1038/s41598-019-56078-7

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