TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (RGNEF) are a hallmark of ALS. Despite intensi...

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Detalles Bibliográficos
Autores principales: Droppelmann, Cristian A., Campos-Melo, Danae, Moszczynski, Alexander J., Amzil, Hind, Strong, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934605/
https://www.ncbi.nlm.nih.gov/pubmed/31882736
http://dx.doi.org/10.1038/s41598-019-56483-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934605/
https://www.ncbi.nlm.nih.gov/pubmed/31882736
http://dx.doi.org/10.1038/s41598-019-56483-y

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