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Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study

Medicated obstructive pulmonary disease (asthma or COPD) has been associated with depression. Yet, there is little knowledge of the interplay of contributing social, biological, behavioral and psychological factors in the community. The study was conducted: (1) To determine the prevalence of depress...

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Autores principales: Ghaemi Kerahrodi, Jasmin, Brähler, Elmar, Wiltink, Jörg, Michal, Matthias, Schulz, Andreas, Wild, Phillip S., Münzel, Thomas, Toenges, Gerrit, Lackner, Karl J., Pfeiffer, Norbert, Beutel, Manfred E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934802/
https://www.ncbi.nlm.nih.gov/pubmed/31882715
http://dx.doi.org/10.1038/s41598-019-56440-9
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author Ghaemi Kerahrodi, Jasmin
Brähler, Elmar
Wiltink, Jörg
Michal, Matthias
Schulz, Andreas
Wild, Phillip S.
Münzel, Thomas
Toenges, Gerrit
Lackner, Karl J.
Pfeiffer, Norbert
Beutel, Manfred E.
author_facet Ghaemi Kerahrodi, Jasmin
Brähler, Elmar
Wiltink, Jörg
Michal, Matthias
Schulz, Andreas
Wild, Phillip S.
Münzel, Thomas
Toenges, Gerrit
Lackner, Karl J.
Pfeiffer, Norbert
Beutel, Manfred E.
author_sort Ghaemi Kerahrodi, Jasmin
collection PubMed
description Medicated obstructive pulmonary disease (asthma or COPD) has been associated with depression. Yet, there is little knowledge of the interplay of contributing social, biological, behavioral and psychological factors in the community. The study was conducted: (1) To determine the prevalence of depression in participants with medicated COPD or asthma from the general population, (2) to identify underlying social, biological, behavioral and psychological factors and (3) to determine the contribution of obstructive pulmonary disease and depression to subjective health. The population-based sample of 15.010 study participants (35–74 years) from the Gutenberg Health Study (GHS) was queried according to a medical diagnosis of obstructive pulmonary disease, defined as medicated COPD or asthma, and comorbid disorders. Demographic, behavioral and psychological factors were assessed by self-report; lung function (FEV1; FCV) was measured by spirometry. 307 men (4.3%) and 396 women (5.6%) reported a medical diagnosis of COPD or asthma. The prevalence of depression (PHQ-9 > = 10) was twice as high (16.2% vs. 7.5%) compared to participants without obstructive pulmonary disease. Participants with obstructive pulmonary disease were older, had a lower SES, more comorbid diseases and cardiovascular risk factors, higher distress and took more psychotropic medication. In multivariable logistic regression analyses, obstructive pulmonary disease was associated with a 71% increase of depression (OR = 1.71; 95% CI = 1.30 to 2.24). Additional contributors were FEV1 (1.18; 95% CI = 1.05 to 1.32) and dyspnea (NYHA > = 1) (2.19; 1.82 to 2.64), sex (women) (OR = 1.73; 95% CI 1.41 to 2.12), lower SES (OR = 0.98; 95%CI = 0.96 to 0.99). Lack of active sports OR = 0.79; 95% CI 0.68 to 0.92), obesity (OR 1.27; 95% CI 1.07 to 1.50), smoking (OR = 1.26; 95% CI 1.06 to 1.49) and dyslipidemia (OR = 1.35; 95% CI 1.15 to 1.57) also increased the risk of depression. Additional psychological risks were social phobia, type D, low social support, loneliness and life events in the past 12 months. In multivariable linear regression analyses, obstructive pulmonary disease and depression independently contributed to reduced subjective health in addition to sedentary behavior, smoking and comorbid somatic and mental disorders. These findings provide evidence that COPD and asthma are associated with depression in the community. Complex underlying demographic, medical and psychosocial variables have been identified which may justify an integrative treatment approach. Promoting health behavior (smoking cessation, exercising, weight reduction) and social integration may not only improve the somatic course of the disease, but also mental health. Mental health treatment may also improve health behavior and subjective health.
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spelling pubmed-69348022019-12-31 Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study Ghaemi Kerahrodi, Jasmin Brähler, Elmar Wiltink, Jörg Michal, Matthias Schulz, Andreas Wild, Phillip S. Münzel, Thomas Toenges, Gerrit Lackner, Karl J. Pfeiffer, Norbert Beutel, Manfred E. Sci Rep Article Medicated obstructive pulmonary disease (asthma or COPD) has been associated with depression. Yet, there is little knowledge of the interplay of contributing social, biological, behavioral and psychological factors in the community. The study was conducted: (1) To determine the prevalence of depression in participants with medicated COPD or asthma from the general population, (2) to identify underlying social, biological, behavioral and psychological factors and (3) to determine the contribution of obstructive pulmonary disease and depression to subjective health. The population-based sample of 15.010 study participants (35–74 years) from the Gutenberg Health Study (GHS) was queried according to a medical diagnosis of obstructive pulmonary disease, defined as medicated COPD or asthma, and comorbid disorders. Demographic, behavioral and psychological factors were assessed by self-report; lung function (FEV1; FCV) was measured by spirometry. 307 men (4.3%) and 396 women (5.6%) reported a medical diagnosis of COPD or asthma. The prevalence of depression (PHQ-9 > = 10) was twice as high (16.2% vs. 7.5%) compared to participants without obstructive pulmonary disease. Participants with obstructive pulmonary disease were older, had a lower SES, more comorbid diseases and cardiovascular risk factors, higher distress and took more psychotropic medication. In multivariable logistic regression analyses, obstructive pulmonary disease was associated with a 71% increase of depression (OR = 1.71; 95% CI = 1.30 to 2.24). Additional contributors were FEV1 (1.18; 95% CI = 1.05 to 1.32) and dyspnea (NYHA > = 1) (2.19; 1.82 to 2.64), sex (women) (OR = 1.73; 95% CI 1.41 to 2.12), lower SES (OR = 0.98; 95%CI = 0.96 to 0.99). Lack of active sports OR = 0.79; 95% CI 0.68 to 0.92), obesity (OR 1.27; 95% CI 1.07 to 1.50), smoking (OR = 1.26; 95% CI 1.06 to 1.49) and dyslipidemia (OR = 1.35; 95% CI 1.15 to 1.57) also increased the risk of depression. Additional psychological risks were social phobia, type D, low social support, loneliness and life events in the past 12 months. In multivariable linear regression analyses, obstructive pulmonary disease and depression independently contributed to reduced subjective health in addition to sedentary behavior, smoking and comorbid somatic and mental disorders. These findings provide evidence that COPD and asthma are associated with depression in the community. Complex underlying demographic, medical and psychosocial variables have been identified which may justify an integrative treatment approach. Promoting health behavior (smoking cessation, exercising, weight reduction) and social integration may not only improve the somatic course of the disease, but also mental health. Mental health treatment may also improve health behavior and subjective health. Nature Publishing Group UK 2019-12-27 /pmc/articles/PMC6934802/ /pubmed/31882715 http://dx.doi.org/10.1038/s41598-019-56440-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ghaemi Kerahrodi, Jasmin
Brähler, Elmar
Wiltink, Jörg
Michal, Matthias
Schulz, Andreas
Wild, Phillip S.
Münzel, Thomas
Toenges, Gerrit
Lackner, Karl J.
Pfeiffer, Norbert
Beutel, Manfred E.
Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
title Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
title_full Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
title_fullStr Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
title_full_unstemmed Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
title_short Association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
title_sort association between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based gutenberg health study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934802/
https://www.ncbi.nlm.nih.gov/pubmed/31882715
http://dx.doi.org/10.1038/s41598-019-56440-9
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