c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect of c-Cbl on the tumor microenvironment remains poorly understood. Here we demonstrate that c-Cbl alters the tumor microenvironment and sup...

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Detalles Bibliográficos
Autores principales: Lyle, Chimera, Richards, Sean, Yasuda, Kei, Napoleon, Marc Arthur, Walker, Joshua, Arinze, Nkiruka, Belghasem, Mostafa, Vellard, Irva, Yin, Wenqing, Ravid, Jonathan D., Zavaro, Elias, Amraei, Razie, Francis, Jean, Phatak, Uma, Rifkin, Ian R., Rahimi, Nader, Chitalia, Vipul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934810/
https://www.ncbi.nlm.nih.gov/pubmed/31882749
http://dx.doi.org/10.1038/s41598-019-56208-1

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