Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

Actomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC. However, the distinct...

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Detalles Bibliográficos
Autores principales: Srinivasan, Srisathya, Das, Sreya, Surve, Vishakha, Srivastava, Ankita, Kumar, Sushant, Jain, Nikita, Sawant, Abhijeet, Nayak, Chitra, Purwar, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934852/
https://www.ncbi.nlm.nih.gov/pubmed/31882703
http://dx.doi.org/10.1038/s41598-019-56447-2

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