Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL

The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CN...

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Autores principales: Farhadian, Shelli F, Mistry, Hetal, Kirchwey, Tobias, Chiarella, Jennifer, Calvi, Rachela, Chintanaphol, Michelle, Patel, Payal, Landry, Marie L, Robertson, Kevin, Spudich, Serena S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934883/
https://www.ncbi.nlm.nih.gov/pubmed/31893212
http://dx.doi.org/10.1093/ofid/ofz528
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author Farhadian, Shelli F
Mistry, Hetal
Kirchwey, Tobias
Chiarella, Jennifer
Calvi, Rachela
Chintanaphol, Michelle
Patel, Payal
Landry, Marie L
Robertson, Kevin
Spudich, Serena S
author_facet Farhadian, Shelli F
Mistry, Hetal
Kirchwey, Tobias
Chiarella, Jennifer
Calvi, Rachela
Chintanaphol, Michelle
Patel, Payal
Landry, Marie L
Robertson, Kevin
Spudich, Serena S
author_sort Farhadian, Shelli F
collection PubMed
description The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood–brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing.
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spelling pubmed-69348832019-12-31 Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL Farhadian, Shelli F Mistry, Hetal Kirchwey, Tobias Chiarella, Jennifer Calvi, Rachela Chintanaphol, Michelle Patel, Payal Landry, Marie L Robertson, Kevin Spudich, Serena S Open Forum Infect Dis Brief Report The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood–brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing. Oxford University Press 2019-12-14 /pmc/articles/PMC6934883/ /pubmed/31893212 http://dx.doi.org/10.1093/ofid/ofz528 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Farhadian, Shelli F
Mistry, Hetal
Kirchwey, Tobias
Chiarella, Jennifer
Calvi, Rachela
Chintanaphol, Michelle
Patel, Payal
Landry, Marie L
Robertson, Kevin
Spudich, Serena S
Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
title Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
title_full Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
title_fullStr Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
title_full_unstemmed Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
title_short Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL
title_sort markers of cns injury in adults living with hiv with csf hiv not detected vs detected <20 copies/ml
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934883/
https://www.ncbi.nlm.nih.gov/pubmed/31893212
http://dx.doi.org/10.1093/ofid/ofz528
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