Cargando…

Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study

BACKGROUND/OBJECTIVES: Non-caloric artificial sweeteners (NAS) are marketed as healthier alternatives to sugar, but the relationship between consumption of NAS and development of diabetes is unclear. This study assessed the associations of diet soda and NAS consumption with: (1) early markers of ins...

Descripción completa

Detalles Bibliográficos
Autores principales: Jensen, Paul N., Howard, Barbara V., Best, Lyle, O'Leary, Marcia, Devereux, Richard B., Cole, Shelley A., MacCluer, Jean W., Ali, Tauqeer, Lee, Elisa T., Yeh, Fawn L., Yeh, Jeunliang, Umans, Jason G., Fretts, Amanda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934923/
https://www.ncbi.nlm.nih.gov/pubmed/31253876
http://dx.doi.org/10.1038/s41430-019-0461-6
_version_ 1783483489056718848
author Jensen, Paul N.
Howard, Barbara V.
Best, Lyle
O'Leary, Marcia
Devereux, Richard B.
Cole, Shelley A.
MacCluer, Jean W.
Ali, Tauqeer
Lee, Elisa T.
Yeh, Fawn L.
Yeh, Jeunliang
Umans, Jason G.
Fretts, Amanda M.
author_facet Jensen, Paul N.
Howard, Barbara V.
Best, Lyle
O'Leary, Marcia
Devereux, Richard B.
Cole, Shelley A.
MacCluer, Jean W.
Ali, Tauqeer
Lee, Elisa T.
Yeh, Fawn L.
Yeh, Jeunliang
Umans, Jason G.
Fretts, Amanda M.
author_sort Jensen, Paul N.
collection PubMed
description BACKGROUND/OBJECTIVES: Non-caloric artificial sweeteners (NAS) are marketed as healthier alternatives to sugar, but the relationship between consumption of NAS and development of diabetes is unclear. This study assessed the associations of diet soda and NAS consumption with: (1) early markers of insulin and glucose homeostasis (cross-sectionally); and (2) incident diabetes (over an average of 8 years of follow-up) among American Indians, a population with high rates of obesity. SUBJECTS/METHODS: The study population included Strong Heart Family Study participants without cardiovascular disease or diabetes who participated in the 2007-2009 study exam (n=1,359). Diet soda and NAS consumption were assessed using a Block food frequency questionnaire and supplemental NAS questionnaire at the study exam. Fasting plasma glucose and insulin were measured during the study exam after a 12-hour overnight fast. Participants were followed for incident diabetes through December 2017 using a single phone interview and medical record review; diabetes was identified by self-report and confirmed by documentation in medical records. Associations of diet soda and NAS consumption with fasting insulin, glucose and incident diabetes were assessed using generalized estimating equations (fasting insulin and glucose analyses) and parametric survival models with Weibull distributions (incident diabetes analyses). RESULTS: Just under half of participants reported regularly consuming diet soda (40%) or using NAS to sweeten their beverages (41%). During an average 8 years of follow-up, we identified 98 cases of incident diabetes. After correction for multiple comparisons, there were no statistically significant associations of reported diet soda and NAS consumption with fasting insulin, fasting glucose, or incident diabetes. CONCLUSIONS: Although reported consumption of diet soda and NAS were high, neither were associated with diabetes risk.
format Online
Article
Text
id pubmed-6934923
institution National Center for Biotechnology Information
language English
publishDate 2019
record_format MEDLINE/PubMed
spelling pubmed-69349232019-12-29 Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study Jensen, Paul N. Howard, Barbara V. Best, Lyle O'Leary, Marcia Devereux, Richard B. Cole, Shelley A. MacCluer, Jean W. Ali, Tauqeer Lee, Elisa T. Yeh, Fawn L. Yeh, Jeunliang Umans, Jason G. Fretts, Amanda M. Eur J Clin Nutr Article BACKGROUND/OBJECTIVES: Non-caloric artificial sweeteners (NAS) are marketed as healthier alternatives to sugar, but the relationship between consumption of NAS and development of diabetes is unclear. This study assessed the associations of diet soda and NAS consumption with: (1) early markers of insulin and glucose homeostasis (cross-sectionally); and (2) incident diabetes (over an average of 8 years of follow-up) among American Indians, a population with high rates of obesity. SUBJECTS/METHODS: The study population included Strong Heart Family Study participants without cardiovascular disease or diabetes who participated in the 2007-2009 study exam (n=1,359). Diet soda and NAS consumption were assessed using a Block food frequency questionnaire and supplemental NAS questionnaire at the study exam. Fasting plasma glucose and insulin were measured during the study exam after a 12-hour overnight fast. Participants were followed for incident diabetes through December 2017 using a single phone interview and medical record review; diabetes was identified by self-report and confirmed by documentation in medical records. Associations of diet soda and NAS consumption with fasting insulin, glucose and incident diabetes were assessed using generalized estimating equations (fasting insulin and glucose analyses) and parametric survival models with Weibull distributions (incident diabetes analyses). RESULTS: Just under half of participants reported regularly consuming diet soda (40%) or using NAS to sweeten their beverages (41%). During an average 8 years of follow-up, we identified 98 cases of incident diabetes. After correction for multiple comparisons, there were no statistically significant associations of reported diet soda and NAS consumption with fasting insulin, fasting glucose, or incident diabetes. CONCLUSIONS: Although reported consumption of diet soda and NAS were high, neither were associated with diabetes risk. 2019-06-28 2020-02 /pmc/articles/PMC6934923/ /pubmed/31253876 http://dx.doi.org/10.1038/s41430-019-0461-6 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Jensen, Paul N.
Howard, Barbara V.
Best, Lyle
O'Leary, Marcia
Devereux, Richard B.
Cole, Shelley A.
MacCluer, Jean W.
Ali, Tauqeer
Lee, Elisa T.
Yeh, Fawn L.
Yeh, Jeunliang
Umans, Jason G.
Fretts, Amanda M.
Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study
title Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study
title_full Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study
title_fullStr Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study
title_full_unstemmed Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study
title_short Associations of Diet Soda and Non-Caloric Artificial Sweetener Use with Markers of Glucose and Insulin Homeostasis and Incident Diabetes: the Strong Heart Family Study
title_sort associations of diet soda and non-caloric artificial sweetener use with markers of glucose and insulin homeostasis and incident diabetes: the strong heart family study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934923/
https://www.ncbi.nlm.nih.gov/pubmed/31253876
http://dx.doi.org/10.1038/s41430-019-0461-6
work_keys_str_mv AT jensenpauln associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT howardbarbarav associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT bestlyle associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT olearymarcia associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT devereuxrichardb associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT coleshelleya associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT maccluerjeanw associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT alitauqeer associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT leeelisat associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT yehfawnl associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT yehjeunliang associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT umansjasong associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy
AT frettsamandam associationsofdietsodaandnoncaloricartificialsweetenerusewithmarkersofglucoseandinsulinhomeostasisandincidentdiabetesthestrongheartfamilystudy