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Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing

The antimicrobial activity of a wound dressing is a key factor for preventing and treating wound infection. The current study evaluated the physiochemical properties and antimicrobial activities of semi-IPNs (interpenetrating polymer networks) based on chitosan/polyvinyl alcohol (PVA) films and nano...

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Autores principales: Hedayatyanfard, Keshvad, Bagheri-Khoulenjani, Shadab, Hashemi, Ali, Ziai, Seyed Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934968/
https://www.ncbi.nlm.nih.gov/pubmed/32641929
http://dx.doi.org/10.22037/ijpr.2019.1100712
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author Hedayatyanfard, Keshvad
Bagheri-Khoulenjani, Shadab
Hashemi, Ali
Ziai, Seyed Ali
author_facet Hedayatyanfard, Keshvad
Bagheri-Khoulenjani, Shadab
Hashemi, Ali
Ziai, Seyed Ali
author_sort Hedayatyanfard, Keshvad
collection PubMed
description The antimicrobial activity of a wound dressing is a key factor for preventing and treating wound infection. The current study evaluated the physiochemical properties and antimicrobial activities of semi-IPNs (interpenetrating polymer networks) based on chitosan/polyvinyl alcohol (PVA) films and nanofibers as candidates for wound dressings and investigated the effects of morphologies (nanofibrous mats and films), crosslinking conditions of chitosan chains (uncrosslinked and crosslinked with genipin), and the presence of antibacterial drug (doxycycline) on their physicochemical and antibacterial properties. The morphology, chemical structure, fluid uptake, water vapor transmission rate, antimicrobial activity, and doxycycline release profile were assayed using SEM, FTIR spectroscopy, swelling test, permeation test, agar diffusion antibiogram, and dissolution test, respectively. The results demonstrated that crosslinking chitosan with genipin reduced the diameter of nanofibers, fluid uptake, and drug release from both nanofiber mats and film samples. According to the results, wound dressings with film morphology have better antimicrobial activity than those with nanofiber. The chitosan/PVA/Doxycycline 1% film has the potential for use as an antimicrobial wound dressing.
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spelling pubmed-69349682020-07-07 Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing Hedayatyanfard, Keshvad Bagheri-Khoulenjani, Shadab Hashemi, Ali Ziai, Seyed Ali Iran J Pharm Res Original Article The antimicrobial activity of a wound dressing is a key factor for preventing and treating wound infection. The current study evaluated the physiochemical properties and antimicrobial activities of semi-IPNs (interpenetrating polymer networks) based on chitosan/polyvinyl alcohol (PVA) films and nanofibers as candidates for wound dressings and investigated the effects of morphologies (nanofibrous mats and films), crosslinking conditions of chitosan chains (uncrosslinked and crosslinked with genipin), and the presence of antibacterial drug (doxycycline) on their physicochemical and antibacterial properties. The morphology, chemical structure, fluid uptake, water vapor transmission rate, antimicrobial activity, and doxycycline release profile were assayed using SEM, FTIR spectroscopy, swelling test, permeation test, agar diffusion antibiogram, and dissolution test, respectively. The results demonstrated that crosslinking chitosan with genipin reduced the diameter of nanofibers, fluid uptake, and drug release from both nanofiber mats and film samples. According to the results, wound dressings with film morphology have better antimicrobial activity than those with nanofiber. The chitosan/PVA/Doxycycline 1% film has the potential for use as an antimicrobial wound dressing. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC6934968/ /pubmed/32641929 http://dx.doi.org/10.22037/ijpr.2019.1100712 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hedayatyanfard, Keshvad
Bagheri-Khoulenjani, Shadab
Hashemi, Ali
Ziai, Seyed Ali
Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing
title Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing
title_full Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing
title_fullStr Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing
title_full_unstemmed Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing
title_short Semi-IPN Films and Electrospun Nanofibers Based on Chitosan/PVA as an Antibacterial Wound Dressing
title_sort semi-ipn films and electrospun nanofibers based on chitosan/pva as an antibacterial wound dressing
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934968/
https://www.ncbi.nlm.nih.gov/pubmed/32641929
http://dx.doi.org/10.22037/ijpr.2019.1100712
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