Cargando…
Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study
BACKGROUND: Previous genome-wide association studies have found two single nucleotide polymorphisms (SNP) rs7692387 and rs1842896 located on or near the GUCY1A3 gene were associated with coronary artery disease (CAD). GUCY1A3 was considered to be involved in the process of atherosclerosis, but there...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935057/ https://www.ncbi.nlm.nih.gov/pubmed/31883534 http://dx.doi.org/10.1186/s12944-019-1177-2 |
_version_ | 1783483507543113728 |
---|---|
author | Li, Jian-li Liu, Liu-yu Jiang, Dong-dong Jiang, Yi-ying Zhou, Guo-qiu Mo, Dong-can Luo, Man |
author_facet | Li, Jian-li Liu, Liu-yu Jiang, Dong-dong Jiang, Yi-ying Zhou, Guo-qiu Mo, Dong-can Luo, Man |
author_sort | Li, Jian-li |
collection | PubMed |
description | BACKGROUND: Previous genome-wide association studies have found two single nucleotide polymorphisms (SNP) rs7692387 and rs1842896 located on or near the GUCY1A3 gene were associated with coronary artery disease (CAD). GUCY1A3 was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of the GUCY1A3 and large artery atherosclerotic (LAA) stroke. This study aimed to investigate the associations between the GUCY1A3 rs7692387, rs1842896 polymorphisms and LAA stroke susceptibility. METHODS: A total of 298 LAA stroke patients and 300 control subjects from a southern Chinese Han population were included. SNaPshot technique was used for genotype analysis. Associations between genotypes and LAA stroke susceptibility were analyzed with logistic regression model. RESULTS: Our study found that under the recessive model (TT vs. GT + GG), the GUCY1A3 rs1842896 polymorphism was significantly correlated with LAA stroke (OR = 1.48, 95%CI: 1.07–2.04, P = 0.018). After adjustment for its effects on age, gender, cigarette smoking, total cholesterol, low-density lipoprotein cholesterol, HbA1c, hypertension, diabetes mellitus, and CAD, the rs1842896 TT genotype retained association with increased susceptibility to LAA stroke (recessive model: adjusted OR = 1.96, 95%CI: 1.22–3.17, P = 0.006). However, association between rs7692387 polymorphism with LAA stroke was not observed. CONCLUSION: Our results indicate that the GUCY1A3 rs1842896 polymorphism is an LAA stroke risk factor in Southern Han Chinese. |
format | Online Article Text |
id | pubmed-6935057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69350572019-12-30 Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study Li, Jian-li Liu, Liu-yu Jiang, Dong-dong Jiang, Yi-ying Zhou, Guo-qiu Mo, Dong-can Luo, Man Lipids Health Dis Research BACKGROUND: Previous genome-wide association studies have found two single nucleotide polymorphisms (SNP) rs7692387 and rs1842896 located on or near the GUCY1A3 gene were associated with coronary artery disease (CAD). GUCY1A3 was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of the GUCY1A3 and large artery atherosclerotic (LAA) stroke. This study aimed to investigate the associations between the GUCY1A3 rs7692387, rs1842896 polymorphisms and LAA stroke susceptibility. METHODS: A total of 298 LAA stroke patients and 300 control subjects from a southern Chinese Han population were included. SNaPshot technique was used for genotype analysis. Associations between genotypes and LAA stroke susceptibility were analyzed with logistic regression model. RESULTS: Our study found that under the recessive model (TT vs. GT + GG), the GUCY1A3 rs1842896 polymorphism was significantly correlated with LAA stroke (OR = 1.48, 95%CI: 1.07–2.04, P = 0.018). After adjustment for its effects on age, gender, cigarette smoking, total cholesterol, low-density lipoprotein cholesterol, HbA1c, hypertension, diabetes mellitus, and CAD, the rs1842896 TT genotype retained association with increased susceptibility to LAA stroke (recessive model: adjusted OR = 1.96, 95%CI: 1.22–3.17, P = 0.006). However, association between rs7692387 polymorphism with LAA stroke was not observed. CONCLUSION: Our results indicate that the GUCY1A3 rs1842896 polymorphism is an LAA stroke risk factor in Southern Han Chinese. BioMed Central 2019-12-28 /pmc/articles/PMC6935057/ /pubmed/31883534 http://dx.doi.org/10.1186/s12944-019-1177-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Li, Jian-li Liu, Liu-yu Jiang, Dong-dong Jiang, Yi-ying Zhou, Guo-qiu Mo, Dong-can Luo, Man Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study |
title | Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study |
title_full | Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study |
title_fullStr | Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study |
title_full_unstemmed | Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study |
title_short | Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study |
title_sort | associations between gucy1a3 genetic polymorphisms and large artery atherosclerotic stroke risk in chinese han population: a case-control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935057/ https://www.ncbi.nlm.nih.gov/pubmed/31883534 http://dx.doi.org/10.1186/s12944-019-1177-2 |
work_keys_str_mv | AT lijianli associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy AT liuliuyu associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy AT jiangdongdong associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy AT jiangyiying associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy AT zhouguoqiu associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy AT modongcan associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy AT luoman associationsbetweengucy1a3geneticpolymorphismsandlargearteryatheroscleroticstrokeriskinchinesehanpopulationacasecontrolstudy |