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S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis

BACKGROUND: PIK3CA mutations are frequent in human breast cancer. Pik3caH1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 mutations co-occur with PIK3CA mutations in human breast cancers. We previously generated a conditionally activatable Pik3caH1047R;MMTV-Cre mouse model...

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Detalles Bibliográficos
Autores principales:	Yuan, Wenlin, Goldstein, Leonard D., Durinck, Steffen, Chen, Ying-Jiun, Nguyen, Thong T., Kljavin, Noelyn M., Sokol, Ethan S., Stawiski, Eric W., Haley, Benjamin, Ziai, James, Modrusan, Zora, Seshagiri, Somasekar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935129/ https://www.ncbi.nlm.nih.gov/pubmed/31881983 http://dx.doi.org/10.1186/s13058-019-1238-5

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