Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide, although its pathogenesis remains to be elucidated. A recent study revealed that hepatic Niemann-Pick C1-Like 1 (NPC1L1), a cholesterol re-absorber from bile to the liver expressed on the bile c...

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Detalles Bibliográficos
Autores principales: Toyoda, Yu, Takada, Tappei, Yamanashi, Yoshihide, Suzuki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935138/
https://www.ncbi.nlm.nih.gov/pubmed/31883528
http://dx.doi.org/10.1186/s12944-019-1179-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935138/
https://www.ncbi.nlm.nih.gov/pubmed/31883528
http://dx.doi.org/10.1186/s12944-019-1179-0

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