The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

OBJECTIVE: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women...

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Detalles Bibliográficos
Autores principales: Womersley, Jacqueline S., Clauss, Lara B., Varathan, Olivette, Engelbrecht, Susan, Hemmings, Sian M. J., Seedat, Soraya, Spies, Georgina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935155/
https://www.ncbi.nlm.nih.gov/pubmed/31881924
http://dx.doi.org/10.1186/s13104-019-4869-9
Descripción
Sumario:OBJECTIVE: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. RESULTS: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).

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