The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

OBJECTIVE: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women...

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Autores principales: Womersley, Jacqueline S., Clauss, Lara B., Varathan, Olivette, Engelbrecht, Susan, Hemmings, Sian M. J., Seedat, Soraya, Spies, Georgina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935155/
https://www.ncbi.nlm.nih.gov/pubmed/31881924
http://dx.doi.org/10.1186/s13104-019-4869-9
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author Womersley, Jacqueline S.
Clauss, Lara B.
Varathan, Olivette
Engelbrecht, Susan
Hemmings, Sian M. J.
Seedat, Soraya
Spies, Georgina
author_facet Womersley, Jacqueline S.
Clauss, Lara B.
Varathan, Olivette
Engelbrecht, Susan
Hemmings, Sian M. J.
Seedat, Soraya
Spies, Georgina
author_sort Womersley, Jacqueline S.
collection PubMed
description OBJECTIVE: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. RESULTS: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).
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spelling pubmed-69351552019-12-30 The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance Womersley, Jacqueline S. Clauss, Lara B. Varathan, Olivette Engelbrecht, Susan Hemmings, Sian M. J. Seedat, Soraya Spies, Georgina BMC Res Notes Research Note OBJECTIVE: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. RESULTS: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039). BioMed Central 2019-12-27 /pmc/articles/PMC6935155/ /pubmed/31881924 http://dx.doi.org/10.1186/s13104-019-4869-9 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Womersley, Jacqueline S.
Clauss, Lara B.
Varathan, Olivette
Engelbrecht, Susan
Hemmings, Sian M. J.
Seedat, Soraya
Spies, Georgina
The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
title The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
title_full The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
title_fullStr The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
title_full_unstemmed The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
title_short The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
title_sort effect of childhood trauma, apoe genotype and hiv-1 viral protein r variants on change in cognitive performance
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935155/
https://www.ncbi.nlm.nih.gov/pubmed/31881924
http://dx.doi.org/10.1186/s13104-019-4869-9
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