Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37

BACKGROUND: LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important component of the nuclear pore complex (NPC), whose elevated expression is associat...

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Detalles Bibliográficos
Autores principales: Chen, Jinxiao, Wo, Da, Ma, En, Yan, Hongwei, Peng, Jun, Zhu, Weidong, Fang, Yong, Ren, Dan-ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935199/
https://www.ncbi.nlm.nih.gov/pubmed/31881970
http://dx.doi.org/10.1186/s12964-019-0495-3

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