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The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia

INTRODUCTION: Early detection and treatment of dysglycemia including diabetes and prediabetes is demonstrated to improve disease outcomes and prevent complications. OBJECTIVE: To assess the association of prediabetes with lipid metabolism disorders to clarify whether systematic screening for prediab...

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Autores principales: Al Amri, Turki, Bahijri, Suhad, Al-Raddadi, Rajaa, Ajabnoor, Ghada, Al Ahmadi, Jawaher, Jambi, Hanan, Borai, Anwar, Tuomilehto, Jaakko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935271/
https://www.ncbi.nlm.nih.gov/pubmed/31920353
http://dx.doi.org/10.2147/DMSO.S233717
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author Al Amri, Turki
Bahijri, Suhad
Al-Raddadi, Rajaa
Ajabnoor, Ghada
Al Ahmadi, Jawaher
Jambi, Hanan
Borai, Anwar
Tuomilehto, Jaakko
author_facet Al Amri, Turki
Bahijri, Suhad
Al-Raddadi, Rajaa
Ajabnoor, Ghada
Al Ahmadi, Jawaher
Jambi, Hanan
Borai, Anwar
Tuomilehto, Jaakko
author_sort Al Amri, Turki
collection PubMed
description INTRODUCTION: Early detection and treatment of dysglycemia including diabetes and prediabetes is demonstrated to improve disease outcomes and prevent complications. OBJECTIVE: To assess the association of prediabetes with lipid metabolism disorders to clarify whether systematic screening for prediabetes should be proposed for individuals with dyslipidemia. MATERIAL AND METHODS: A cross-sectional study design, employing a stratified two-stage cluster sampling method recruited non-diabetic adults (age ≥18 years) from attendees of Primary Health Care (PHC) centers in Jeddah. Anthropomorphic measurements, demographic and clinical information were taken, and blood pressure was measured. Fasting blood sample was obtained for the measurement of plasma glucose (FPG), glycated hemoglobin (HbA1C), and lipid profile. Plasma glucose was estimated 1 hr after the ingestion of 50 g glucose (1h-OGTT). Prediabetes and dyslipidemia were defined according to international guidelines. Demographic and clinical factors of subjects with prediabetes, and those with normoglycemia were compared. Multiple logistic regression analysis was used to adjust for confounding factors. RESULTS: A total of 613 individuals were included with a mean age (±SD) of 32±11.8years, and 54.8% being female. Prediabetes was detected in 28.7%, and dyslipidemia in 54.2% of participants. After adjusting for age, an association was found for high low-density lipoprotein-cholesterol (LDL-C) and prediabetes based on any definition. After adjustment for body mass index (BMI), the association was retained for any type of dyslipidemia and in particular high LDL-C. After adjusting for both age and BMI, a significant association was found only between high LDL-C and prediabetes based on any definition (OR, 95% CI=1.50,1.02–2.19, P= 0.037). CONCLUSION: Even though high LDL-C is associated with an increased probability of prediabetes, a recommendation for universal screening of dyslipidemic patients requires further cohort studies.
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spelling pubmed-69352712020-01-09 The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia Al Amri, Turki Bahijri, Suhad Al-Raddadi, Rajaa Ajabnoor, Ghada Al Ahmadi, Jawaher Jambi, Hanan Borai, Anwar Tuomilehto, Jaakko Diabetes Metab Syndr Obes Original Research INTRODUCTION: Early detection and treatment of dysglycemia including diabetes and prediabetes is demonstrated to improve disease outcomes and prevent complications. OBJECTIVE: To assess the association of prediabetes with lipid metabolism disorders to clarify whether systematic screening for prediabetes should be proposed for individuals with dyslipidemia. MATERIAL AND METHODS: A cross-sectional study design, employing a stratified two-stage cluster sampling method recruited non-diabetic adults (age ≥18 years) from attendees of Primary Health Care (PHC) centers in Jeddah. Anthropomorphic measurements, demographic and clinical information were taken, and blood pressure was measured. Fasting blood sample was obtained for the measurement of plasma glucose (FPG), glycated hemoglobin (HbA1C), and lipid profile. Plasma glucose was estimated 1 hr after the ingestion of 50 g glucose (1h-OGTT). Prediabetes and dyslipidemia were defined according to international guidelines. Demographic and clinical factors of subjects with prediabetes, and those with normoglycemia were compared. Multiple logistic regression analysis was used to adjust for confounding factors. RESULTS: A total of 613 individuals were included with a mean age (±SD) of 32±11.8years, and 54.8% being female. Prediabetes was detected in 28.7%, and dyslipidemia in 54.2% of participants. After adjusting for age, an association was found for high low-density lipoprotein-cholesterol (LDL-C) and prediabetes based on any definition. After adjustment for body mass index (BMI), the association was retained for any type of dyslipidemia and in particular high LDL-C. After adjusting for both age and BMI, a significant association was found only between high LDL-C and prediabetes based on any definition (OR, 95% CI=1.50,1.02–2.19, P= 0.037). CONCLUSION: Even though high LDL-C is associated with an increased probability of prediabetes, a recommendation for universal screening of dyslipidemic patients requires further cohort studies. Dove 2019-12-24 /pmc/articles/PMC6935271/ /pubmed/31920353 http://dx.doi.org/10.2147/DMSO.S233717 Text en © 2019 Al Amri et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Al Amri, Turki
Bahijri, Suhad
Al-Raddadi, Rajaa
Ajabnoor, Ghada
Al Ahmadi, Jawaher
Jambi, Hanan
Borai, Anwar
Tuomilehto, Jaakko
The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia
title The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia
title_full The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia
title_fullStr The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia
title_full_unstemmed The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia
title_short The Association Between Prediabetes and Dyslipidemia Among Attendants of Primary Care Health Centers in Jeddah, Saudi Arabia
title_sort association between prediabetes and dyslipidemia among attendants of primary care health centers in jeddah, saudi arabia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935271/
https://www.ncbi.nlm.nih.gov/pubmed/31920353
http://dx.doi.org/10.2147/DMSO.S233717
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