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Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial

BACKGROUND: Administration of steroids in the lumbar transforaminal block for lumbar radicular pain is considered one of the preferred treatment methods though it is associated with some complications. OBJECTIVES: The effects and side effects of triamcinolone and dexmedetomidine in the lumbar transf...

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Autores principales: Imani, Farnad, Rahimzadeh, Poupak, Khademi, Seyed-Hossein, Narimani Zamanabadi, Mahnaz, Sadegi, Kambiz, Abolfazli-Karizi, Abouzar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935293/
https://www.ncbi.nlm.nih.gov/pubmed/31903335
http://dx.doi.org/10.5812/aapm.96117
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author Imani, Farnad
Rahimzadeh, Poupak
Khademi, Seyed-Hossein
Narimani Zamanabadi, Mahnaz
Sadegi, Kambiz
Abolfazli-Karizi, Abouzar
author_facet Imani, Farnad
Rahimzadeh, Poupak
Khademi, Seyed-Hossein
Narimani Zamanabadi, Mahnaz
Sadegi, Kambiz
Abolfazli-Karizi, Abouzar
author_sort Imani, Farnad
collection PubMed
description BACKGROUND: Administration of steroids in the lumbar transforaminal block for lumbar radicular pain is considered one of the preferred treatment methods though it is associated with some complications. OBJECTIVES: The effects and side effects of triamcinolone and dexmedetomidine in the lumbar transforaminal block were investigated in the present study. METHODS: In this study, 30 patients, aged 40 - 70 years, suffering from lumbar radicular pain arising from the lumbar disc protrusion were equally divided into two groups of triamcinolone (T) and dexmedetomidine (D). They all underwent lumbar transforaminal blocks. An injection solution of triamcinolone (20 mg) plus ropivacaine (0.2%) and another one containing dexmedetomidine (50 μg) plus ropivacaine (0.2%) were administered in the triamcinolone and dexmedetomidine groups, respectively. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Straight Leg Raise (SLR or lasègue’s test), and Fasting Blood Sugar (FBS) were measured at 0, 2 weeks, 1, 3, and 6 months post-procedure. The levels of calcium, magnesium, and vitamin D, as well as potential complications, were also evaluated. RESULTS: Significant differences were found in the VAS and ODI during the measurement times within each group. The VAS and ODI were remarkably different between the dexmedetomidine group and the triamcinolone group. In addition, there were considerable differences in the increased FBS and reduced calcium and vitamin D levels in the triamcinolone group from changes in the dexmedetomidine group. CONCLUSIONS: The lumbar transforaminal block with triamcinolone or dexmedetomidine attenuates the lumbar radicular pain. Further, dexmedetomidine exerts a more potent pain relief effect than triamcinolone.
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spelling pubmed-69352932020-01-03 Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial Imani, Farnad Rahimzadeh, Poupak Khademi, Seyed-Hossein Narimani Zamanabadi, Mahnaz Sadegi, Kambiz Abolfazli-Karizi, Abouzar Anesth Pain Med Research Article BACKGROUND: Administration of steroids in the lumbar transforaminal block for lumbar radicular pain is considered one of the preferred treatment methods though it is associated with some complications. OBJECTIVES: The effects and side effects of triamcinolone and dexmedetomidine in the lumbar transforaminal block were investigated in the present study. METHODS: In this study, 30 patients, aged 40 - 70 years, suffering from lumbar radicular pain arising from the lumbar disc protrusion were equally divided into two groups of triamcinolone (T) and dexmedetomidine (D). They all underwent lumbar transforaminal blocks. An injection solution of triamcinolone (20 mg) plus ropivacaine (0.2%) and another one containing dexmedetomidine (50 μg) plus ropivacaine (0.2%) were administered in the triamcinolone and dexmedetomidine groups, respectively. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Straight Leg Raise (SLR or lasègue’s test), and Fasting Blood Sugar (FBS) were measured at 0, 2 weeks, 1, 3, and 6 months post-procedure. The levels of calcium, magnesium, and vitamin D, as well as potential complications, were also evaluated. RESULTS: Significant differences were found in the VAS and ODI during the measurement times within each group. The VAS and ODI were remarkably different between the dexmedetomidine group and the triamcinolone group. In addition, there were considerable differences in the increased FBS and reduced calcium and vitamin D levels in the triamcinolone group from changes in the dexmedetomidine group. CONCLUSIONS: The lumbar transforaminal block with triamcinolone or dexmedetomidine attenuates the lumbar radicular pain. Further, dexmedetomidine exerts a more potent pain relief effect than triamcinolone. Kowsar 2019-10-23 /pmc/articles/PMC6935293/ /pubmed/31903335 http://dx.doi.org/10.5812/aapm.96117 Text en Copyright © 2019, Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Imani, Farnad
Rahimzadeh, Poupak
Khademi, Seyed-Hossein
Narimani Zamanabadi, Mahnaz
Sadegi, Kambiz
Abolfazli-Karizi, Abouzar
Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial
title Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial
title_full Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial
title_fullStr Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial
title_full_unstemmed Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial
title_short Comparison of Transforaminal Triamcinolone and Dexmedetomidine in Radicular Low-Back Pain: A Randomized Double-Blind Clinical Trial
title_sort comparison of transforaminal triamcinolone and dexmedetomidine in radicular low-back pain: a randomized double-blind clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935293/
https://www.ncbi.nlm.nih.gov/pubmed/31903335
http://dx.doi.org/10.5812/aapm.96117
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