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ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by homozygous mutation or deletion of the survival motor neuron 1 (SMN1) gene. A second copy, SMN2, is similar to SMN1 but produces ∼10% SMN protein because of a single-point mutation that causes splicing defects. Chronic low levels of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935747/ https://www.ncbi.nlm.nih.gov/pubmed/31828288 http://dx.doi.org/10.1093/brain/awz373 |