Cargando…

Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke

OBJECTIVE: To research the clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke (LCA-AIS). METHODS: Patients diagnosed with LCA-AIS, simple lung cancer, and simple AIS were enrolled. The primary information, laboratory results, tumor histopathology, neurological...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Jiacai, Wu, Siting, Xu, Rui, Shi, Qiang, Tian, Chenglin, Cui, Fang, Shao, Xue, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935791/
https://www.ncbi.nlm.nih.gov/pubmed/31930131
http://dx.doi.org/10.1155/2019/6021037
_version_ 1783483632984260608
author Lin, Jiacai
Wu, Siting
Xu, Rui
Shi, Qiang
Tian, Chenglin
Cui, Fang
Shao, Xue
Liu, Hui
author_facet Lin, Jiacai
Wu, Siting
Xu, Rui
Shi, Qiang
Tian, Chenglin
Cui, Fang
Shao, Xue
Liu, Hui
author_sort Lin, Jiacai
collection PubMed
description OBJECTIVE: To research the clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke (LCA-AIS). METHODS: Patients diagnosed with LCA-AIS, simple lung cancer, and simple AIS were enrolled. The primary information, laboratory results, tumor histopathology, neurological deficits, and survival time of the patients were collected and analyzed. RESULTS: (1) In the LCA-AIS group, the pathology of 69.56% patients were adenocarcinoma, and the proportion of poorly differentiated patients was significantly more than that in moderately differentiated or highly differentiated. The number of stage IV lung cancer patients in the LCA-AIS group was significantly more common than in other stages. (2) 56.52% of patients with lung cancer were diagnosed before AIS, and the peak of AIS attack was 1–6 months after the diagnosis of lung cancer. (3) The independent risk factors of LCA-AIS were CYFRA-211 (OR 1.070; 95% confidence interval 1.005, 1.139; p = 0.035), TT (OR 1.275; 95% confidence interval 1.089, 1.493; p = 0.003), and Hct (OR 0.878; 95% confidence interval 0.779, 0.990; p = 0.034), making ROC curve, suggesting the area under the curve is 0.871. (4) The neurological deficit of patients in the LCA-AIS group was similar to the simple AIS group and could not be identified by the severity of neurological deficits. (5) The median survival time of LCA-AIS group patients was five months (95% confidence interval 3.796, 6.204). There were statistical differences in survival time between LCA-AIS group and simple AIS group patients (p < 0.001). CONCLUSIONS: The interaction between lung cancer and AIS may shorten patients' life expectancy and worsen their quality of life.
format Online
Article
Text
id pubmed-6935791
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-69357912020-01-10 Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke Lin, Jiacai Wu, Siting Xu, Rui Shi, Qiang Tian, Chenglin Cui, Fang Shao, Xue Liu, Hui Biomed Res Int Research Article OBJECTIVE: To research the clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke (LCA-AIS). METHODS: Patients diagnosed with LCA-AIS, simple lung cancer, and simple AIS were enrolled. The primary information, laboratory results, tumor histopathology, neurological deficits, and survival time of the patients were collected and analyzed. RESULTS: (1) In the LCA-AIS group, the pathology of 69.56% patients were adenocarcinoma, and the proportion of poorly differentiated patients was significantly more than that in moderately differentiated or highly differentiated. The number of stage IV lung cancer patients in the LCA-AIS group was significantly more common than in other stages. (2) 56.52% of patients with lung cancer were diagnosed before AIS, and the peak of AIS attack was 1–6 months after the diagnosis of lung cancer. (3) The independent risk factors of LCA-AIS were CYFRA-211 (OR 1.070; 95% confidence interval 1.005, 1.139; p = 0.035), TT (OR 1.275; 95% confidence interval 1.089, 1.493; p = 0.003), and Hct (OR 0.878; 95% confidence interval 0.779, 0.990; p = 0.034), making ROC curve, suggesting the area under the curve is 0.871. (4) The neurological deficit of patients in the LCA-AIS group was similar to the simple AIS group and could not be identified by the severity of neurological deficits. (5) The median survival time of LCA-AIS group patients was five months (95% confidence interval 3.796, 6.204). There were statistical differences in survival time between LCA-AIS group and simple AIS group patients (p < 0.001). CONCLUSIONS: The interaction between lung cancer and AIS may shorten patients' life expectancy and worsen their quality of life. Hindawi 2019-12-17 /pmc/articles/PMC6935791/ /pubmed/31930131 http://dx.doi.org/10.1155/2019/6021037 Text en Copyright © 2019 Jiacai Lin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Jiacai
Wu, Siting
Xu, Rui
Shi, Qiang
Tian, Chenglin
Cui, Fang
Shao, Xue
Liu, Hui
Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke
title Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke
title_full Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke
title_fullStr Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke
title_full_unstemmed Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke
title_short Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke
title_sort clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935791/
https://www.ncbi.nlm.nih.gov/pubmed/31930131
http://dx.doi.org/10.1155/2019/6021037
work_keys_str_mv AT linjiacai clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT wusiting clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT xurui clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT shiqiang clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT tianchenglin clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT cuifang clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT shaoxue clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke
AT liuhui clinicalcharacteristicsandriskfactorsoflungcancerassociatedacuteischemicstroke