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mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity

BACKGROUND: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus understanding how this protein leads to the selective re-pr...

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Detalles Bibliográficos
Autores principales:	Waldron, Joseph A., Tack, David C., Ritchey, Laura E., Gillen, Sarah L., Wilczynska, Ania, Turro, Ernest, Bevilacqua, Philip C., Assmann, Sarah M., Bushell, Martin, Le Quesne, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936103/ https://www.ncbi.nlm.nih.gov/pubmed/31888698 http://dx.doi.org/10.1186/s13059-019-1901-2

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