Loss of TOP3B leads to increased R-loop formation and genome instability

Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease. A homozygous deletion for the TOP3B gene was identified in a patient with bilateral renal...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Wallis, Mathew, Petrovic, Vida, Challis, Jackie, Kalitsis, Paul, Hudson, Damien F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936252/
https://www.ncbi.nlm.nih.gov/pubmed/31795919
http://dx.doi.org/10.1098/rsob.190222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936252/
https://www.ncbi.nlm.nih.gov/pubmed/31795919
http://dx.doi.org/10.1098/rsob.190222

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