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Individual structural features constrain the mouse functional connectome
Whole brain dynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional connectome is unknown, even though its importance is uncontested. After acquiring structural data from individual mice, we v...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936369/ https://www.ncbi.nlm.nih.gov/pubmed/31826956 http://dx.doi.org/10.1073/pnas.1906694116 |
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author | Melozzi, Francesca Bergmann, Eyal Harris, Julie A. Kahn, Itamar Jirsa, Viktor Bernard, Christophe |
author_facet | Melozzi, Francesca Bergmann, Eyal Harris, Julie A. Kahn, Itamar Jirsa, Viktor Bernard, Christophe |
author_sort | Melozzi, Francesca |
collection | PubMed |
description | Whole brain dynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional connectome is unknown, even though its importance is uncontested. After acquiring structural data from individual mice, we virtualized their brain networks and simulated in silico functional MRI data. Theoretical results were validated against empirical awake functional MRI data obtained from the same mice. We demonstrate that individual structural connectomes predict the functional organization of individual brains. Using a virtual mouse brain derived from the Allen Mouse Brain Connectivity Atlas, we further show that the dominant predictors of individual structure–function relations are the asymmetry and the weights of the structural links. Model predictions were validated experimentally using tracer injections, identifying which missing connections (not measurable with diffusion MRI) are important for whole brain dynamics in the mouse. Individual variations thus define a specific structural fingerprint with direct impact upon the functional organization of individual brains, a key feature for personalized medicine. |
format | Online Article Text |
id | pubmed-6936369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-69363692019-12-31 Individual structural features constrain the mouse functional connectome Melozzi, Francesca Bergmann, Eyal Harris, Julie A. Kahn, Itamar Jirsa, Viktor Bernard, Christophe Proc Natl Acad Sci U S A PNAS Plus Whole brain dynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional connectome is unknown, even though its importance is uncontested. After acquiring structural data from individual mice, we virtualized their brain networks and simulated in silico functional MRI data. Theoretical results were validated against empirical awake functional MRI data obtained from the same mice. We demonstrate that individual structural connectomes predict the functional organization of individual brains. Using a virtual mouse brain derived from the Allen Mouse Brain Connectivity Atlas, we further show that the dominant predictors of individual structure–function relations are the asymmetry and the weights of the structural links. Model predictions were validated experimentally using tracer injections, identifying which missing connections (not measurable with diffusion MRI) are important for whole brain dynamics in the mouse. Individual variations thus define a specific structural fingerprint with direct impact upon the functional organization of individual brains, a key feature for personalized medicine. National Academy of Sciences 2019-12-26 2019-12-11 /pmc/articles/PMC6936369/ /pubmed/31826956 http://dx.doi.org/10.1073/pnas.1906694116 Text en Copyright © 2019 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | PNAS Plus Melozzi, Francesca Bergmann, Eyal Harris, Julie A. Kahn, Itamar Jirsa, Viktor Bernard, Christophe Individual structural features constrain the mouse functional connectome |
title | Individual structural features constrain the mouse functional connectome |
title_full | Individual structural features constrain the mouse functional connectome |
title_fullStr | Individual structural features constrain the mouse functional connectome |
title_full_unstemmed | Individual structural features constrain the mouse functional connectome |
title_short | Individual structural features constrain the mouse functional connectome |
title_sort | individual structural features constrain the mouse functional connectome |
topic | PNAS Plus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936369/ https://www.ncbi.nlm.nih.gov/pubmed/31826956 http://dx.doi.org/10.1073/pnas.1906694116 |
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