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Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib

We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic...

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Autores principales: Mendoza Alvarez, Lybil Briscia, Liu, Xiuli, Glover, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936404/
https://www.ncbi.nlm.nih.gov/pubmed/31831517
http://dx.doi.org/10.1136/bcr-2019-232558
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author Mendoza Alvarez, Lybil Briscia
Liu, Xiuli
Glover, Sarah
author_facet Mendoza Alvarez, Lybil Briscia
Liu, Xiuli
Glover, Sarah
author_sort Mendoza Alvarez, Lybil Briscia
collection PubMed
description We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments. There was a significant improvement in the appearance of the oesophagus as well as the least number of eosinophils found in oesophagus biopsies after 3 months of treatment with tofacitinib. There are no cases of EoE treated with tofacitinib. Tofacitinib should be considered for the treatment of eosinophilic oesophagitis given its evolving role as an immunosuppressive agent.
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spelling pubmed-69364042020-01-06 Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib Mendoza Alvarez, Lybil Briscia Liu, Xiuli Glover, Sarah BMJ Case Rep Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments. There was a significant improvement in the appearance of the oesophagus as well as the least number of eosinophils found in oesophagus biopsies after 3 months of treatment with tofacitinib. There are no cases of EoE treated with tofacitinib. Tofacitinib should be considered for the treatment of eosinophilic oesophagitis given its evolving role as an immunosuppressive agent. BMJ Publishing Group 2019-12-11 /pmc/articles/PMC6936404/ /pubmed/31831517 http://dx.doi.org/10.1136/bcr-2019-232558 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
Mendoza Alvarez, Lybil Briscia
Liu, Xiuli
Glover, Sarah
Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
title Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
title_full Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
title_fullStr Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
title_full_unstemmed Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
title_short Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
title_sort treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
topic Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936404/
https://www.ncbi.nlm.nih.gov/pubmed/31831517
http://dx.doi.org/10.1136/bcr-2019-232558
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