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Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib
We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936404/ https://www.ncbi.nlm.nih.gov/pubmed/31831517 http://dx.doi.org/10.1136/bcr-2019-232558 |
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author | Mendoza Alvarez, Lybil Briscia Liu, Xiuli Glover, Sarah |
author_facet | Mendoza Alvarez, Lybil Briscia Liu, Xiuli Glover, Sarah |
author_sort | Mendoza Alvarez, Lybil Briscia |
collection | PubMed |
description | We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments. There was a significant improvement in the appearance of the oesophagus as well as the least number of eosinophils found in oesophagus biopsies after 3 months of treatment with tofacitinib. There are no cases of EoE treated with tofacitinib. Tofacitinib should be considered for the treatment of eosinophilic oesophagitis given its evolving role as an immunosuppressive agent. |
format | Online Article Text |
id | pubmed-6936404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-69364042020-01-06 Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib Mendoza Alvarez, Lybil Briscia Liu, Xiuli Glover, Sarah BMJ Case Rep Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments. There was a significant improvement in the appearance of the oesophagus as well as the least number of eosinophils found in oesophagus biopsies after 3 months of treatment with tofacitinib. There are no cases of EoE treated with tofacitinib. Tofacitinib should be considered for the treatment of eosinophilic oesophagitis given its evolving role as an immunosuppressive agent. BMJ Publishing Group 2019-12-11 /pmc/articles/PMC6936404/ /pubmed/31831517 http://dx.doi.org/10.1136/bcr-2019-232558 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) Mendoza Alvarez, Lybil Briscia Liu, Xiuli Glover, Sarah Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
title | Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
title_full | Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
title_fullStr | Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
title_full_unstemmed | Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
title_short | Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
title_sort | treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib |
topic | Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936404/ https://www.ncbi.nlm.nih.gov/pubmed/31831517 http://dx.doi.org/10.1136/bcr-2019-232558 |
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