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Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality

INTRODUCTION: Gavi, the Vaccine Alliance, was set up in 2000 to improve access to vaccines for children living in the poorest countries. Funding has increased significantly over time, with Gavi disbursements reaching US $1.58 billion in 2015. We assess whether Gavi’s funding programmes have indeed i...

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Autores principales: Jaupart, Pascal, Dipple, Lizzie, Dercon, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936423/
https://www.ncbi.nlm.nih.gov/pubmed/31908857
http://dx.doi.org/10.1136/bmjgh-2019-001789
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author Jaupart, Pascal
Dipple, Lizzie
Dercon, Stefan
author_facet Jaupart, Pascal
Dipple, Lizzie
Dercon, Stefan
author_sort Jaupart, Pascal
collection PubMed
description INTRODUCTION: Gavi, the Vaccine Alliance, was set up in 2000 to improve access to vaccines for children living in the poorest countries. Funding has increased significantly over time, with Gavi disbursements reaching US $1.58 billion in 2015. We assess whether Gavi’s funding programmes have indeed increased immunisation coverage in 51 recipient countries for two key vaccines for 12–23 month olds: combined diphtheria, pertussis and tetanus (DPT) and measles. Additionally, we look at effects on infant and child mortality. METHODS: Taking a difference-in-differences quasi-experimental approach to observational data, we estimate the impact of Gavi eligibility on immunisation coverage and mortality rates over time, using WHO/UNICEF figures covering 1995–2016. We control for economy size and population of each country as well as running a suite of robustness checks and sensitivity tests. RESULTS: We find large and significant positive effects from Gavi’s funding programmes: on average a 12.02 percentage point increase in DPT immunisation coverage (95% CI 6.56 to 17.49) and an 8.81 percentage point increase in measles immunisation coverage (95% CI 3.58 to 14.04) over the period to 2016. Our estimates show Gavi support also induced 6.22 fewer infant deaths (95% CI −10.47 to −1.97) and 12.23 fewer under-five deaths (95% CI −19.66 to −4.79) per 1000 live births. CONCLUSION: Our findings provide evidence that Gavi has had a substantial impact on the fight against communicable diseases for improved population and child health in lower-income countries. In this case, the health policy to verticalise aid—specifically development assistance for health—via a specialised global fund has had positive outcomes.
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spelling pubmed-69364232020-01-06 Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality Jaupart, Pascal Dipple, Lizzie Dercon, Stefan BMJ Glob Health Research INTRODUCTION: Gavi, the Vaccine Alliance, was set up in 2000 to improve access to vaccines for children living in the poorest countries. Funding has increased significantly over time, with Gavi disbursements reaching US $1.58 billion in 2015. We assess whether Gavi’s funding programmes have indeed increased immunisation coverage in 51 recipient countries for two key vaccines for 12–23 month olds: combined diphtheria, pertussis and tetanus (DPT) and measles. Additionally, we look at effects on infant and child mortality. METHODS: Taking a difference-in-differences quasi-experimental approach to observational data, we estimate the impact of Gavi eligibility on immunisation coverage and mortality rates over time, using WHO/UNICEF figures covering 1995–2016. We control for economy size and population of each country as well as running a suite of robustness checks and sensitivity tests. RESULTS: We find large and significant positive effects from Gavi’s funding programmes: on average a 12.02 percentage point increase in DPT immunisation coverage (95% CI 6.56 to 17.49) and an 8.81 percentage point increase in measles immunisation coverage (95% CI 3.58 to 14.04) over the period to 2016. Our estimates show Gavi support also induced 6.22 fewer infant deaths (95% CI −10.47 to −1.97) and 12.23 fewer under-five deaths (95% CI −19.66 to −4.79) per 1000 live births. CONCLUSION: Our findings provide evidence that Gavi has had a substantial impact on the fight against communicable diseases for improved population and child health in lower-income countries. In this case, the health policy to verticalise aid—specifically development assistance for health—via a specialised global fund has had positive outcomes. BMJ Publishing Group 2019-12-03 /pmc/articles/PMC6936423/ /pubmed/31908857 http://dx.doi.org/10.1136/bmjgh-2019-001789 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research
Jaupart, Pascal
Dipple, Lizzie
Dercon, Stefan
Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality
title Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality
title_full Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality
title_fullStr Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality
title_full_unstemmed Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality
title_short Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality
title_sort has gavi lived up to its promise? quasi-experimental evidence on country immunisation rates and child mortality
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936423/
https://www.ncbi.nlm.nih.gov/pubmed/31908857
http://dx.doi.org/10.1136/bmjgh-2019-001789
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