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Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study
OBJECTIVE: To investigate whether the health implications of having type 2 diabetes (T2D) were different in South Asian compared with white European participants. RESEARCH DESIGN AND METHODS: Prospective data from UK Biobank were used, and 457 935 participants of white European and 7102 of South Asi...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936483/ https://www.ncbi.nlm.nih.gov/pubmed/31908795 http://dx.doi.org/10.1136/bmjdrc-2019-000765 |
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author | Muilwijk, Mirthe Ho, Frederick Waddell, Heather Sillars, Anne Welsh, Paul Iliodromiti, Stamatina Brown, Rosemary Ferguson, Lyn Stronks, Karien van Valkengoed, Irene Pell, Jill P Gray, Stuart Robert Gill, Jason Martin Regnald Sattar, Naveed Celis-Morales, Carlos |
author_facet | Muilwijk, Mirthe Ho, Frederick Waddell, Heather Sillars, Anne Welsh, Paul Iliodromiti, Stamatina Brown, Rosemary Ferguson, Lyn Stronks, Karien van Valkengoed, Irene Pell, Jill P Gray, Stuart Robert Gill, Jason Martin Regnald Sattar, Naveed Celis-Morales, Carlos |
author_sort | Muilwijk, Mirthe |
collection | PubMed |
description | OBJECTIVE: To investigate whether the health implications of having type 2 diabetes (T2D) were different in South Asian compared with white European participants. RESEARCH DESIGN AND METHODS: Prospective data from UK Biobank were used, and 457 935 participants of white European and 7102 of South Asian background were included. Cox proportional regression was performed to investigate the association between T2D and health outcome by ethnicity. RESULTS: Over a mean of 7.0 years (IQR 6.3–7.6) of follow-up, 12 974 participants had died, and 30 347 and 27 159 developed cardiovascular disease (CVD) and cancer, respectively. South Asians had a higher risk for CVD mortality (HR: 1.42, 95% CI 1.07 to 1.89) and incidence (HR: 1.78, 95% CI 1.63 to 1.94), but a decreased risk for cancer mortality (HR: 0.59, 95% CI 0.41 to 0.85) and incidence (HR: 0.80, 95% CI 0.70 to 0.92) compared with white Europeans. Compared with individuals without T2D, both white Europeans and South Asians with T2D had a higher risk for all-cause mortality (1.59 (1.48 to 1.71) vs 2.83 (1.76 to 4.53)), CVD mortality (2.04 (1.82 to 2.28) vs 4.40 (2.37 to 8.16)) and CVD incidence (1.37 (1.31 to 1.44) vs 1.60 (1.31 to 1.95)), respectively. However, the magnitude of the risk was higher for South Asians than white Europeans. CONCLUSIONS: Although T2D was associated with a higher risk for all-cause mortality and CVD incidence and mortality, in both white Europeans and South Asians, the risk experienced by South Asians with T2D was higher than their white European counterparts. |
format | Online Article Text |
id | pubmed-6936483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-69364832020-01-06 Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study Muilwijk, Mirthe Ho, Frederick Waddell, Heather Sillars, Anne Welsh, Paul Iliodromiti, Stamatina Brown, Rosemary Ferguson, Lyn Stronks, Karien van Valkengoed, Irene Pell, Jill P Gray, Stuart Robert Gill, Jason Martin Regnald Sattar, Naveed Celis-Morales, Carlos BMJ Open Diabetes Res Care Epidemiology/Health Services Research OBJECTIVE: To investigate whether the health implications of having type 2 diabetes (T2D) were different in South Asian compared with white European participants. RESEARCH DESIGN AND METHODS: Prospective data from UK Biobank were used, and 457 935 participants of white European and 7102 of South Asian background were included. Cox proportional regression was performed to investigate the association between T2D and health outcome by ethnicity. RESULTS: Over a mean of 7.0 years (IQR 6.3–7.6) of follow-up, 12 974 participants had died, and 30 347 and 27 159 developed cardiovascular disease (CVD) and cancer, respectively. South Asians had a higher risk for CVD mortality (HR: 1.42, 95% CI 1.07 to 1.89) and incidence (HR: 1.78, 95% CI 1.63 to 1.94), but a decreased risk for cancer mortality (HR: 0.59, 95% CI 0.41 to 0.85) and incidence (HR: 0.80, 95% CI 0.70 to 0.92) compared with white Europeans. Compared with individuals without T2D, both white Europeans and South Asians with T2D had a higher risk for all-cause mortality (1.59 (1.48 to 1.71) vs 2.83 (1.76 to 4.53)), CVD mortality (2.04 (1.82 to 2.28) vs 4.40 (2.37 to 8.16)) and CVD incidence (1.37 (1.31 to 1.44) vs 1.60 (1.31 to 1.95)), respectively. However, the magnitude of the risk was higher for South Asians than white Europeans. CONCLUSIONS: Although T2D was associated with a higher risk for all-cause mortality and CVD incidence and mortality, in both white Europeans and South Asians, the risk experienced by South Asians with T2D was higher than their white European counterparts. BMJ Publishing Group 2019-12-17 /pmc/articles/PMC6936483/ /pubmed/31908795 http://dx.doi.org/10.1136/bmjdrc-2019-000765 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Epidemiology/Health Services Research Muilwijk, Mirthe Ho, Frederick Waddell, Heather Sillars, Anne Welsh, Paul Iliodromiti, Stamatina Brown, Rosemary Ferguson, Lyn Stronks, Karien van Valkengoed, Irene Pell, Jill P Gray, Stuart Robert Gill, Jason Martin Regnald Sattar, Naveed Celis-Morales, Carlos Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study |
title | Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study |
title_full | Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study |
title_fullStr | Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study |
title_full_unstemmed | Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study |
title_short | Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study |
title_sort | contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white europeans and south asians: findings from the uk biobank population-based cohort study |
topic | Epidemiology/Health Services Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936483/ https://www.ncbi.nlm.nih.gov/pubmed/31908795 http://dx.doi.org/10.1136/bmjdrc-2019-000765 |
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