Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

OBJECTIVE: Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic kidney disease (DKD) and chronic kidney diseases. We tested the hypothesis that human DKD-related i...

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Detalles Bibliográficos
Autores principales: Bian, Xiaohui, Griffin, Tomás P, Zhu, Xiangyang, Islam, Md Nahidul, Conley, Sabena M, Eirin, Alfonso, Tang, Hui, O’Shea, Paula M, Palmer, Allyson K, McCoy, Rozalina G, Herrmann, Sandra M, Mehta, Ramila A, Woollard, John R, Rule, Andrew D, Kirkland, James L, Tchkonia, Tamar, Textor, Stephen C, Griffin, Matthew D, Lerman, Lilach O, Hickson, LaTonya J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Pathophysiology/Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936543/
https://www.ncbi.nlm.nih.gov/pubmed/31908790
http://dx.doi.org/10.1136/bmjdrc-2019-000720

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